{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knudsen-Clark AM"],"funding":["HHS | NIH | National Institute of General Medical Sciences","University of Rochester","NIEHS NIH HHS","UR | URMC | Wilmot Cancer Institute, University of Rochester Medical Center","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","UR | URMC | Wilmot Cancer Institute, University of Rochester Medical Center (WCI)","HHS | NIH | National Cancer Institute","University of Rochester (UR)","NCI NIH HHS","HHS | NIH | National Cancer Institute (NCI)","HHS | NIH | National Institute of General Medical Sciences (NIGMS)","NIGMS NIH HHS"],"pagination":["5080-5112"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11549407"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(11)"],"pubmed_abstract":["Tumor-associated macrophages (TAMs) are prime therapeutic targets due to their pro-tumorigenic functions, but varying efficacy of macrophage-targeting therapies highlights our incomplete understanding of how macrophages are regulated within the tumor microenvironment (TME). The circadian clock is a key regulator of macrophage function, but how circadian rhythms of macrophages are influenced by the TME remains unknown. Here, we show that conditions associated with the TME such as polarizing stimuli, acidic pH, and lactate can alter circadian rhythms in macrophages. While cyclic AMP (cAMP) has been reported to play a role in macrophage response to acidic pH, our results indicate pH-driven changes in circadian rhythms are not mediated solely by cAMP signaling. Remarkably, circadian disorder o"],"journal":["EMBO reports"],"pubmed_title":["Circadian rhythms of macrophages are altered by the acidic tumor microenvironment."],"pmcid":["PMC11549407"],"funding_grant_id":["T32AI007285","R01 CA282225","T32 AI007285","P30 ES001247","No grant number","R00CA204593","R01CA282225","T32GM135134","T32 GM135134","R00 CA204593"],"pubmed_authors":["Knudsen-Clark AM","Hablitz LM","Baker C","Mwangi D","Morris K","McCall MN","Altman BJ","Cazarin J","Kim M"],"additional_accession":[]},"is_claimable":false,"name":"Circadian rhythms of macrophages are altered by the acidic tumor microenvironment.","description":"Tumor-associated macrophages (TAMs) are prime therapeutic targets due to their pro-tumorigenic functions, but varying efficacy of macrophage-targeting therapies highlights our incomplete understanding of how macrophages are regulated within the tumor microenvironment (TME). The circadian clock is a key regulator of macrophage function, but how circadian rhythms of macrophages are influenced by the TME remains unknown. Here, we show that conditions associated with the TME such as polarizing stimuli, acidic pH, and lactate can alter circadian rhythms in macrophages. While cyclic AMP (cAMP) has been reported to play a role in macrophage response to acidic pH, our results indicate pH-driven changes in circadian rhythms are not mediated solely by cAMP signaling. Remarkably, circadian disorder o","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-03T00:51:55.101Z","creation":"2025-04-19T17:28:08.545Z"},"accession":"S-EPMC11549407","cross_references":{"pubmed":["39415049"],"doi":["10.1038/s44319-024-00288-2"]}}