{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["D'Onofrio F"],"funding":["Ministero della Salute"],"pagination":["e39832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11550065"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(21)"],"pubmed_abstract":["<i>Listeria monocytogenes</i> is a significant concern in the food industry due to its association with outbreaks of listeriosis, particularly affecting vulnerable populations. High-throughput technologies such as RNA sequencing (RNA-seq) and proteomics offer valuable insights into the molecular responses of <i>L. monocytogenes</i> to stress environments. In this study, a combined transcriptomic and immunoproteomic approach was applied to explore the stress response mechanisms of the <i>L. monocytogenes</i> strain ST7, which was responsible for an outbreak in central Italy. The bacterium was exposed to both optimal conditions and a stress environment representative of pork product matrices (pH 5.5; 7 % NaCl) and thermal abuse prior to consumption (12 °C).Transcriptomic analysis revealed va"],"journal":["Heliyon"],"pubmed_title":["Integrative analysis of transcriptomic and immunoproteomic data reveals stress response mechanisms in <i>Listeria monocytogenes</i>."],"pmcid":["PMC11550065"],"funding_grant_id":["IZS AM 03/17 RC","MSRCTE0719"],"pubmed_authors":["Tittarelli M","Luciani M","Marcacci M","Pomilio F","Butler F","Di Lollo V","Torresi M","Iannetti L","Krasteva I","Di Pancrazio C","D'Onofrio F","Ancora M","Schirone M","D'Alterio N","Maggetti M","Camma C","Perletta F","Di Domenico M","Sacchini F"],"additional_accession":[]},"is_claimable":false,"name":"Integrative analysis of transcriptomic and immunoproteomic data reveals stress response mechanisms in <i>Listeria monocytogenes</i>.","description":"<i>Listeria monocytogenes</i> is a significant concern in the food industry due to its association with outbreaks of listeriosis, particularly affecting vulnerable populations. High-throughput technologies such as RNA sequencing (RNA-seq) and proteomics offer valuable insights into the molecular responses of <i>L. monocytogenes</i> to stress environments. In this study, a combined transcriptomic and immunoproteomic approach was applied to explore the stress response mechanisms of the <i>L. monocytogenes</i> strain ST7, which was responsible for an outbreak in central Italy. The bacterium was exposed to both optimal conditions and a stress environment representative of pork product matrices (pH 5.5; 7 % NaCl) and thermal abuse prior to consumption (12 °C).Transcriptomic analysis revealed va","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-01T17:33:30.809Z","creation":"2025-04-19T17:28:46.075Z"},"accession":"S-EPMC11550065","cross_references":{"pubmed":["39524754"],"doi":["10.1016/j.heliyon.2024.e39832"]}}