{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(11)"],"submitter":["Furlaneto F"],"funding":["Danisco Sweeteners Oy"],"pubmed_abstract":["<h4>Objective</h4>To evaluate the adjunctive use of the probiotic Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) to conventional therapy on clinical and microbiological parameters in patients with generalized gingivitis.<h4>Methods</h4>Sixty systemically healthy individuals with untreated generalized gingivitis were submitted to periodontal therapy and allocated to receive Placebo (n = 30) or Probiotic (n = 30) lozenges, twice a day for 8 weeks. Bleeding on Marginal Probing (BOMP) was evaluated at baseline, after 2 and 8 weeks. Supra and subgingival biofilm were obtained at baseline and 8 weeks post-therapy for analyses by 16S rRNA gene sequencing. Differences between therapeutic groups were analyzed by non-parametric tests (p<0.05).<h4>Results</h4>The Placebo and Probiotic"],"journal":["PloS one"],"pagination":["e0310529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11554181"],"repository":["biostudies-literature"],"pubmed_title":["Microbiological profile of patients with generalized gingivitis undergoing periodontal therapy and administration of Bifidobacterium animalis subsp. lactis HN019: A randomized clinical trial."],"pmcid":["PMC11554181"],"pubmed_authors":["Salvador SLS","Colombo APV","Silva PHF","da Silveira ICF","Lourenco TGB","Messora MR","Furlaneto F","Levi YLAS","de Oliveira AM","Savio DSF","Ribeiro MC"],"additional_accession":[]},"is_claimable":false,"name":"Microbiological profile of patients with generalized gingivitis undergoing periodontal therapy and administration of Bifidobacterium animalis subsp. lactis HN019: A randomized clinical trial.","description":"<h4>Objective</h4>To evaluate the adjunctive use of the probiotic Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) to conventional therapy on clinical and microbiological parameters in patients with generalized gingivitis.<h4>Methods</h4>Sixty systemically healthy individuals with untreated generalized gingivitis were submitted to periodontal therapy and allocated to receive Placebo (n = 30) or Probiotic (n = 30) lozenges, twice a day for 8 weeks. Bleeding on Marginal Probing (BOMP) was evaluated at baseline, after 2 and 8 weeks. Supra and subgingival biofilm were obtained at baseline and 8 weeks post-therapy for analyses by 16S rRNA gene sequencing. Differences between therapeutic groups were analyzed by non-parametric tests (p<0.05).<h4>Results</h4>The Placebo and Probiotic","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-03T03:17:27.065Z","creation":"2025-04-06T22:46:11.38Z"},"accession":"S-EPMC11554181","cross_references":{"pubmed":["39527605"],"doi":["10.1371/journal.pone.0310529"]}}