{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rai MN"],"funding":["Research Services and Knowledge Transfer Office, University of Macau","Fundo para o Desenvolvimento das Ciências e da Tecnologia"],"pagination":["e73832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11554308"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<i>Candida glabrata</i> can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How <i>C. glabrata</i> reacts inside macrophages and what is the molecular basis of its drug tolerance are not well understood. Here, we mapped genome-wide RNA polymerase II (RNAPII) occupancy in <i>C. glabrata</i> to delineate its transcriptional responses during macrophage infection in high temporal resolution. RNAPII profiles revealed dynamic <i>C. glabrata</i> responses to macrophages with genes of specialized pathways activated chronologically at different times of infection. We identified an uncharacterized transcription factor (CgXbp1) important for the chronological macrophage response, survival in"],"journal":["eLife"],"pubmed_title":["Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance."],"pmcid":["PMC11554308"],"funding_grant_id":["0033/2021/A1","MYRG2019-00099-FHS","MYRG2022-00107-FHS","0099/2022/A2"],"pubmed_authors":["Shen L","Tan K","Rai MN","Parsania C","Lan Q","Wong KH","Rai R","Chen R","Shirgaonkar N"],"additional_accession":[]},"is_claimable":false,"name":"Temporal transcriptional response of <i>Candida glabrata</i> during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and fluconazole resistance.","description":"<i>Candida glabrata</i> can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How <i>C. glabrata</i> reacts inside macrophages and what is the molecular basis of its drug tolerance are not well understood. Here, we mapped genome-wide RNA polymerase II (RNAPII) occupancy in <i>C. glabrata</i> to delineate its transcriptional responses during macrophage infection in high temporal resolution. RNAPII profiles revealed dynamic <i>C. glabrata</i> responses to macrophages with genes of specialized pathways activated chronologically at different times of infection. We identified an uncharacterized transcription factor (CgXbp1) important for the chronological macrophage response, survival in","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-07-09T12:18:27.379Z","creation":"2025-04-07T08:47:02.11Z"},"accession":"S-EPMC11554308","cross_references":{"pubmed":["39356739"],"doi":["10.7554/eLife.73832"]}}