biostudies-literatureWard DDNIA NIH HHS61-71https://www.ebi.ac.uk/biostudies/studies/S-EPMC11555573biostudies-literatureUnknown82(1)<h4>Importance</h4>An accessible marker of both biological age and dementia risk is crucial to advancing dementia prevention and treatment strategies. Although frailty is a candidate for that role, the nature of the relationship between frailty and dementia is not well understood.<h4>Objective</h4>To clarify the temporal relationship between frailty and incident dementia by investigating frailty trajectories in the years preceding dementia onset.<h4>Design, setting, and participants</h4>Participant data came from 4 prospective cohort studies: the English Longitudinal Study of Ageing, the Health and Retirement Study, the Rush Memory and Aging Project, and the National Alzheimer Coordinating Center. Data were collected between 1997 and 2024 and were analyzed from July 2023 to August 2024. ThJAMA neurologyFrailty Trajectories Preceding Dementia in the US and UK.PMC11555573R01 AG073593Hubbard REFoote IFWallace LMKRanson JMStolz ELittlejohns TJCanevelli MWard DDGordon EHFlint JPLlewellyn DJRockwood KfalseFrailty Trajectories Preceding Dementia in the US and UK.<h4>Importance</h4>An accessible marker of both biological age and dementia risk is crucial to advancing dementia prevention and treatment strategies. Although frailty is a candidate for that role, the nature of the relationship between frailty and dementia is not well understood.<h4>Objective</h4>To clarify the temporal relationship between frailty and incident dementia by investigating frailty trajectories in the years preceding dementia onset.<h4>Design, setting, and participants</h4>Participant data came from 4 prospective cohort studies: the English Longitudinal Study of Ageing, the Health and Retirement Study, the Rush Memory and Aging Project, and the National Alzheimer Coordinating Center. Data were collected between 1997 and 2024 and were analyzed from July 2023 to August 2024. Th2025-01-01T00:00:00Z2025 Jan2026-06-05T13:17:09.926Z2026-05-17T03:12:45.623ZS-EPMC115555733952703910.1001/jamaneurol.2024.3774