biostudies-literatureUnknown20(22)Cardaioli F<h4>Background</h4>In patients undergoing transcatheter aortic valve implantation (TAVI), the presence of a low-flow, low-gradient (LFLG) status has been associated with higher mortality at short-term follow-up.<h4>Aims</h4>We aimed to evaluate long-term survival after TAVI in patients with classical (cLFLG) and paradoxical LFLG (pLFLG) aortic stenosis (AS) compared to high-gradient (HG)-AS.<h4>Methods</h4>Patients undergoing TAVI at our centre with a hypothetical minimum 5-year follow-up were divided into 3 groups: (1) HG-AS (mean gradient [MG] >40 mmHg), (2) cLFLG-AS (MG <40 mmHg, ejection fraction [EF] <50%), and (3) pLFLG-AS (MG <40 mmHg, EF ≥50%). The primary endpoint of the study was all-cause mortality. Propensity score-weighted survival analysis was performed to adjust for possibleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology1380-1389https://www.ebi.ac.uk/biostudies/studies/S-EPMC11556328biostudies-literatureLong-term survival after TAVI in low-flow, low-gradient aortic valve stenosis.PMC11556328Fovino LNArturi FFabris TBertolini ANapodano MFraccaro CTarantini GContinisio SCardaioli FLorenzoni GGregori DRodino GMasiero GPanza AfalseLong-term survival after TAVI in low-flow, low-gradient aortic valve stenosis.<h4>Background</h4>In patients undergoing transcatheter aortic valve implantation (TAVI), the presence of a low-flow, low-gradient (LFLG) status has been associated with higher mortality at short-term follow-up.<h4>Aims</h4>We aimed to evaluate long-term survival after TAVI in patients with classical (cLFLG) and paradoxical LFLG (pLFLG) aortic stenosis (AS) compared to high-gradient (HG)-AS.<h4>Methods</h4>Patients undergoing TAVI at our centre with a hypothetical minimum 5-year follow-up were divided into 3 groups: (1) HG-AS (mean gradient [MG] >40 mmHg), (2) cLFLG-AS (MG <40 mmHg, ejection fraction [EF] <50%), and (3) pLFLG-AS (MG <40 mmHg, EF ≥50%). The primary endpoint of the study was all-cause mortality. Propensity score-weighted survival analysis was performed to adjust for possible2024-01-01T00:00:00Z2024 Nov2026-06-09T05:39:44.158Z2026-06-09T03:07:54.769ZS-EPMC115563283955248110.4244/eij-d-24-0044210.4244/EIJ-D-24-00442