{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["38(14)"],"submitter":["Augello M"],"pubmed_abstract":["In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population."],"journal":["AIDS (London, England)"],"pagination":["1987-1990"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11556865"],"repository":["biostudies-literature"],"pubmed_title":["Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV."],"pmcid":["PMC11556865"],"pubmed_authors":["Rovito R","Augello M","Tincati C","Santoro A","Bono V","Marchetti G"],"additional_accession":[]},"is_claimable":false,"name":"Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV.","description":"In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-26T06:08:08.951Z","creation":"2025-04-06T11:45:56.209Z"},"accession":"S-EPMC11556865","cross_references":{"pubmed":["39474654"],"doi":["10.1097/QAD.0000000000004010"]}}