{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jian Z"],"funding":["Hunan Province Natural Sciences Foundation of China"],"pagination":["27744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11557698"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Recently, colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae (CCR-hvKP) has been observed sporadically. The aim of this study was to report a nosocomial outbreak due to CCR-hvKP, so as to control the transmission of CCR-hvKP and prevent future outbreaks. The clinical characteristics of five involved cases were analyzed and infection prevention and control measures were documented. Five CCR-hvKP isolates were discovered from the five involved cases. Molecular features of the isolates including sequence type, capsule locus, antimicrobial resistance genes, virulence factors and phylogenetic relationship were analyzed by whole-genome sequencing. Validation of the role of the deleterious amino acid mutations to colistin resistance was examined by complementation assays. PCR w"],"journal":["Scientific reports"],"pubmed_title":["A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital."],"pmcid":["PMC11557698"],"funding_grant_id":["2021JJ31116"],"pubmed_authors":["Liu Y","Yan Q","Zeng L","Jian Z","Wang Z","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.","description":"Recently, colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae (CCR-hvKP) has been observed sporadically. The aim of this study was to report a nosocomial outbreak due to CCR-hvKP, so as to control the transmission of CCR-hvKP and prevent future outbreaks. The clinical characteristics of five involved cases were analyzed and infection prevention and control measures were documented. Five CCR-hvKP isolates were discovered from the five involved cases. Molecular features of the isolates including sequence type, capsule locus, antimicrobial resistance genes, virulence factors and phylogenetic relationship were analyzed by whole-genome sequencing. Validation of the role of the deleterious amino acid mutations to colistin resistance was examined by complementation assays. PCR w","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-15T08:15:35.598Z","creation":"2025-04-04T00:21:32.462Z"},"accession":"S-EPMC11557698","cross_references":{"pubmed":["39533012"],"doi":["10.1038/s41598-024-79030-w"]}}