{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(10)"],"submitter":["Wen Y"],"pubmed_abstract":["<h4>Purpose</h4>This study explores the detailed effects and mechanisms of Zhi Zhu Ma Ren Pill (ZZMRP) on constipation.<h4>Methods</h4>Mouse constipation was induced by using loperamide (Lop). The effects and mechanisms of ZZMRP on constipation were addressed by various methods including charcoal meals, hematoxylin and eosin (H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL), transmission electron microscopy, and western blot experiments.<h4>Results</h4>Lop-treated mice exhibited delayed transit and reduced ink progradation rates after charcoal meal administration. H&E staining confirmed severe pathologic symptoms in these mice. Additionally, a decline in intersti"],"journal":["American journal of translational research"],"pagination":["5829-5845"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11558397"],"repository":["biostudies-literature"],"pubmed_title":["Zhi Zhu Ma Ren pill relieves constipation in mice through endoplasmic reticulum stress-mediated apoptosis."],"pmcid":["PMC11558397"],"pubmed_authors":["Wen Y","Xu L","Huang C","Li J","Wu R","Zhan Y","Tang X"],"additional_accession":[]},"is_claimable":false,"name":"Zhi Zhu Ma Ren pill relieves constipation in mice through endoplasmic reticulum stress-mediated apoptosis.","description":"<h4>Purpose</h4>This study explores the detailed effects and mechanisms of Zhi Zhu Ma Ren Pill (ZZMRP) on constipation.<h4>Methods</h4>Mouse constipation was induced by using loperamide (Lop). The effects and mechanisms of ZZMRP on constipation were addressed by various methods including charcoal meals, hematoxylin and eosin (H&E) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL), transmission electron microscopy, and western blot experiments.<h4>Results</h4>Lop-treated mice exhibited delayed transit and reduced ink progradation rates after charcoal meal administration. H&E staining confirmed severe pathologic symptoms in these mice. Additionally, a decline in intersti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T17:00:35.777Z","creation":"2025-04-07T04:33:06.758Z"},"accession":"S-EPMC11558397","cross_references":{"pubmed":["39544779"],"doi":["10.62347/ylie1988","10.62347/YLIE1988"]}}