{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["National Cancer Institute","NCI NIH HHS"],"pagination":["1004-1015"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11558792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(4)"],"pubmed_abstract":["The International Agency for Research on Cancer has classified the tobacco-specific nitrosamines <i>N</i>'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as \"carcinogenic to humans\" (Group 1). To exert its carcinogenicity, NNN requires metabolic activation to form reactive intermediates which alkylate DNA. Previous studies have identified cytochrome P450-catalyzed 2'-hydroxylation and 5'-hydroxylation of NNN as major metabolic pathways, with preferential activation through the 5'-hydroxylation pathway in some cultured human tissues and patas monkeys. So far, the only DNA adducts identified from NNN 5'-hydroxylation in rat tissues are 2-[2-(3-pyridyl)-<i>N</i>-pyrrolidinyl]-2'-deoxyinosine (Py-Py-dI), 6-[2-(3-pyridyl)-<i>N</i>-pyrrolidinyl]-2'-deoxynebular"],"journal":["Chemical research in toxicology"],"pubmed_title":["Investigation of 2'-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by &lt;i&gt;N&lt;/i&gt;'-Nitrosonornicotine Metabolism."],"pmcid":["PMC11558792"],"funding_grant_id":["P30 CA077598","R01 CA-81301","R37 CA081301","R01 CA081301","P30 CA-077598"],"pubmed_authors":["Li Y","Zarth AT","Hecht SS","Upadhyaya P","Carlson ES"],"additional_accession":[]},"is_claimable":false,"name":"Investigation of 2'-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by &lt;i&gt;N&lt;/i&gt;'-Nitrosonornicotine Metabolism.","description":"The International Agency for Research on Cancer has classified the tobacco-specific nitrosamines <i>N</i>'-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) as \"carcinogenic to humans\" (Group 1). To exert its carcinogenicity, NNN requires metabolic activation to form reactive intermediates which alkylate DNA. Previous studies have identified cytochrome P450-catalyzed 2'-hydroxylation and 5'-hydroxylation of NNN as major metabolic pathways, with preferential activation through the 5'-hydroxylation pathway in some cultured human tissues and patas monkeys. So far, the only DNA adducts identified from NNN 5'-hydroxylation in rat tissues are 2-[2-(3-pyridyl)-<i>N</i>-pyrrolidinyl]-2'-deoxyinosine (Py-Py-dI), 6-[2-(3-pyridyl)-<i>N</i>-pyrrolidinyl]-2'-deoxynebular","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Apr","modification":"2025-04-04T00:33:48.592Z","creation":"2025-04-04T00:33:48.592Z"},"accession":"S-EPMC11558792","cross_references":{"pubmed":["33720703"],"doi":["10.1021/acs.chemrestox.1c00012"]}}