biostudies-literatureUnknown15Arefanian H<h4>Introduction</h4>Familial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke worldwide. Statins, which inhibit 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the first-choice treatment for dyslipidemias, and have been effective in reducing the risk of stroke and myocardial infarction. However, emerging evidence indicates that statins may increase the incidence of new-onset type 2 diabetes by reducing β-cell mass and function. Notably, past <i>in vitro</i> reports studying the effects of statins on β-cells were performed without including free fatty acids in the model. This factor should have been addressed since these agents are used to treat individuals with hyperlipidemia.<h4>Methods</h4>Frontiers in endocrinology1383448https://www.ebi.ac.uk/biostudies/studies/S-EPMC11560436biostudies-literatureComparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model.PMC11560436Albeloushi SAhmad RQaddoumi MAlmansour NAlzaid FBahman FAl-Mulla FAl Madhoun AWilliams MRArefanian HSindhu SAl-Rashed FfalseComparative efficacy, toxicity, and insulin-suppressive effects of simvastatin and pravastatin in fatty acid-challenged mouse insulinoma MIN6 β-cell model.<h4>Introduction</h4>Familial hypercholesterolemia, the highly prevalent form of dyslipidemia, is a well-known risk factor for premature heart disease and stroke worldwide. Statins, which inhibit 3-hydroxy 3-methylglutaryl coenzyme A (HMG-CoA) reductase, are the first-choice treatment for dyslipidemias, and have been effective in reducing the risk of stroke and myocardial infarction. However, emerging evidence indicates that statins may increase the incidence of new-onset type 2 diabetes by reducing β-cell mass and function. Notably, past <i>in vitro</i> reports studying the effects of statins on β-cells were performed without including free fatty acids in the model. This factor should have been addressed since these agents are used to treat individuals with hyperlipidemia.<h4>Methods</h4>2024-01-01T00:00:00Z20242026-07-16T20:19:02.764Z2025-04-04T14:43:00.147ZS-EPMC115604363954423510.3389/fendo.2024.1383448