biostudies-literaturePatterson Gentile CNational Institute of Neurological Disorders and StrokePfizerNINDS NIH HHSNational Institute of Neurological Disorders and Stroke (NINDS)1217-1229https://www.ebi.ac.uk/biostudies/studies/S-EPMC11560481biostudies-literatureUnknown64(10)<h4>Objectives</h4>We used Cluster Analysis of Migraine-associated Symptoms (CAMS) to critically evaluate current International Classification of Headache Disorders-Third Edition (ICHD-3) migraine-associated symptoms criteria.<h4>Background</h4>Diagnostic criteria play a central role in guiding clinical trial inclusion, and therefore available treatments. Migraine and tension-type headaches (TTH) are differentiated in ICHD-3 by many headache characteristics, including associated symptoms. A diagnosis of probable migraine indicates some but not all features of migraine are met. Photophobia and phonophobia, or nausea and/or vomiting, are required to meet a diagnosis of migraine; however, CAMS-a model that describes associated symptoms across youth with headache-indicates that a broader rangeHeadacheA critical appraisal of the International Classification of Headache Disorders migraine diagnostic criteria based on a retrospective multicenter cross-sectional headache registry study in youth.PMC11560481K23 NS124986K23NS102521K23NS124986K23 NS102521Szperka CLHershey ADPatterson Gentile CfalseA critical appraisal of the International Classification of Headache Disorders migraine diagnostic criteria based on a retrospective multicenter cross-sectional headache registry study in youth.<h4>Objectives</h4>We used Cluster Analysis of Migraine-associated Symptoms (CAMS) to critically evaluate current International Classification of Headache Disorders-Third Edition (ICHD-3) migraine-associated symptoms criteria.<h4>Background</h4>Diagnostic criteria play a central role in guiding clinical trial inclusion, and therefore available treatments. Migraine and tension-type headaches (TTH) are differentiated in ICHD-3 by many headache characteristics, including associated symptoms. A diagnosis of probable migraine indicates some but not all features of migraine are met. Photophobia and phonophobia, or nausea and/or vomiting, are required to meet a diagnosis of migraine; however, CAMS-a model that describes associated symptoms across youth with headache-indicates that a broader range2024-01-01T00:00:00Z2024 Nov-Dec2026-06-05T07:17:24.352Z2026-05-14T03:08:35.04ZS-EPMC115604813946302610.1111/head.14858