biostudies-literatureSaper VEArthritis FoundationIntramural NIH HHSNIAMSEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSRheumatology Research FoundationChildhood Arthritis and Rheumatology Research AllianceNational Institutes of HealthNational Institute of General Medical SciencesFonds Wetenschappelijk OnderzoekNIAMS NIH HHSDavid and Lucile Packard FoundationNIGMS NIH HHSLucile Packard Foundation for Children&apos;s Health2996-3013.e7https://www.ebi.ac.uk/biostudies/studies/S-EPMC11560592biostudies-literatureUnknown12(11)<h4>Background</h4>After introducing IL-1/IL-6 inhibitors, some patients with Still and Still-like disease developed unusual, often fatal, pulmonary disease. This complication was associated with scoring as DReSS (drug reaction with eosinophilia and systemic symptoms) implicating these inhibitors, although DReSS can be difficult to recognize in the setting of systemic inflammatory disease.<h4>Objective</h4>To facilitate recognition of IL-1/IL-6 inhibitor-DReSS in systemic inflammatory illnesses (Still/Still-like) by looking at timing and reaction-associated features. We evaluated outcomes of stopping or not stopping IL-1/IL-6 inhibitors after DReSS reaction began.<h4>Methods</h4>In an international study collaborating primarily with pediatric specialists, we characterized features of 89 drThe journal of allergy and clinical immunology. In practiceInterleukin (IL)-1/IL-6-Inhibitor-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses.PMC11560592Z01AR041198ZIA AR041198T32HD104576T32 HD104576T32 AR050942T32GM086330T32 GM086330Aviran Dagan NTaneja AOrandi AShehab ARafko JRuth NEdelheit BSDalrymple ARiordan MWoolnough LFlanagan ENigrovic PTodd CBlakley MMcCurdy DLapin WBKitcharoensakkul MVerbsky JTheisen ATaber SJindal AKNassi LHahn TLevy DLapin BWeiser PDedeoglu FBolaria RFigueroa CMiller MManos COberle EShenoi SAlmutairi AGrim AAl Julandani DMatchett DVega-Fernandez PKienzle BHenrickson MStringer ECollinge JPaller ASura AWaite HSelmanovic VWhite ACorrell CWong STian LTory HCiaglia KChang-Hoftman ASantiago LZeft AKlein KZhu AHickey KPuplava BDrew JRodgers LMoreno JQuinlan-Waters MSchmeling HRamsey SHong SModica RReed ADu QEdelheit BMoyer ADavis TSchutt CPaul SRothman DTse SFernandez-Vina MASchahn JVerstegen RGoh IRavelli ABradfield HRodriquez MFlanagan ERGriffin TOnel KAllenspach EMarston BSadun RSharma SNeely JGilbert MSule SBinstadt BSpencer CBingham CACurry MChiraseveenuprapund PChen ABaszis KKlausmeier TBenseler SPonder LFailing CMachado ARandell RLBingham CVerstegen RHJDevine RJohnson LJohnson NMa MHoffart CSullivan JKlein-Gitelman MSHiraki LWeiss JChalom EJanow GKuo CSPerron MAkinsete ABrothers MDriest KWeiss PCanna SNativ SMurante BAbdul-Aziz RRichins SLasky ASyed RSon MBYasin SStevens BWhitehead BAkoghlanian SHarris JBader-Meunier BLawler CSrinivasalu HDean JCastro DCooper JYomogida KPatrick ARay LLaxer RRosenkranz MMcColl JNanda KBeil EConlon HSmitherman EArdoin SStewart KFox MNewhall LOmbrello MJBigley TBohnsack JBarillas-Arias LOgbu ESefic Pasic IAl Manaa MBaxter SFox EGoswami NCassidy ESabbagh SCartwright VLimenis EKramer SLake CNajafi AStern SHays KLo MOgbonnaya-Whittesley SSinger NVan Mater HCook KWalters HVannoy LLevinsky YLloyd MGuevara MKimura YThomas BFavier LLytch ABehrens EBridges JHamda Natur MThomas NThomas LChang JMason TTibaldi JKnight AChang MGoldsmith DSchneider RRonis THammond TSchlefman ABullock DStewart WBlack CLing NImundo LFKingsbury DImundo LDeGuzman MWahezi DMombourquette JSoep JSzymanski AHollander MCassidy EAHobday PLeisinger EMellins ELang BHuie LCo DLvovich SDancey PMcBrearty KWay EESchulert GGennaro VMohan SSosna DTesher MZemel LSRupp JMacMahon JGrom AValcarcel TBegezda ARampone KHarel LDhalla MShilo NRMian ZNasah NToib DTwachtman-Bassett JBecker MMannion MEde KKasinathan SAngeles-Han SSchikler KSaad NTorok KSWalker BSivaraman VMitacek RVandenbergen SFutch-West TRosenwasser NSmith CAlBijadi AVora SSmith JNatter MToledano APRabinovich CLovell DCooper AOliver MPan NKim HASoep JBHuberts ASiegel DMarmor IStapp HParsons APatrizi SVarghese CWright TJames KScalzi LMeidan EWilliams CPatel PBermudez-Santiago LSloan ETaylor JFerguson ISpiegel LMcAllister LPatel JHuber ARife ESyverson GCorbin KPandya JKudas OLin CHersh ADeCoste CStevenson RBacha CFeldman BBhattad STaber SFSpitznagle JTwilt MZhao YArmendariz SLentini LReiff DBlackmon BBuckley MStoll MBuckley LFadrhonc SRosado AHuggins JDuncan ELapidus SHorne ABaxter SKKafisheh DRiebschleger MOlveda RFerguson PHarry OShirley JSundel RMilojevic DMiettunen PWidrick KHsu JKremer CMuscal ELuca NCohen ELapsia CADrapeau NBalay-Dustrude EEBasiaga MHay ALieberman SRubinstein TMcDonald JFogel LSwayne NHiskey MVasquez-Canizares NBrunner HDvergsten JHammelev ETate LTing TOzen SFair DGlaser DCollins KPBoneparth ARahimi HRothermel HSaper VEIsupova EASutter MGottlieb BGrevich SNocton JPanupattanapong SLaFlam TLi SJones JTambralli AFuhlbrigge RHausmann JCidon MLerman MFranklin LJiang YFurey MJackson AHalyabar OValdovinos RPhadke OMansfield LSener SSaper VVasquez NEspada GFennell JAamir RAmarilyo GDissanayake DCanny SAmoruso MWaterfield MMoore TMoore KPooni RDunnock KZhang YHopper RKReid HTsin CVillacis Nunez DSBukulmez HLim LYeung RDe Ranieri DJared SWaters AKlaus GDizon BBalevic SNowicki KLivny RKasapcopur OToth MPoholek CConnor RRiskalla MTaxter ABallinger SHayward KKlein-Gitelman MCannon LHorton DDeSantis EMadison JMurphy AMwizerwa OHenderson LRothschild EPeskin MOakes RTal RTanner TLee PMcDaniels KKessler EAsfaw LMoorthy LThakurdeen TVelez JSherman MInman CLee ALopez-Pena MWestheuser VLawson ERobinson ADEdens CEl Tal THolland MAdams AGagne SPadam JSymington TKim SCo DOLee TTarvin SWershba EDickinson AMSwaffar CCARRA Registry InvestigatorsVallee AReinhardt AHorwitz MGerstbacher DWu EKaur RJones JTNearanz KStingl CBrooks EStephens ANolan BSeper COsoegawa KIbarra MElder Mvon Scheven EKostik MMHui-Yuen JRoth-Wojcicki EPrahalad SBernal WLionetti GEberhard AAbulaban KAmbler WOgunjimi BRouster-Stevens KCron RKahn PSteigerwald KConrad CKBaluta SGraham TBerard RAWagner-Weiner LPerfetto JBalboni ISarkissian AYalcindag AKaidar KLong AAlvarez MBTsin CMLawson EFImlay ADurkee DElzaki YDhanrajani ATorok KDatyner EGironella ASchultz KRogers DAlperin RRandell RSterba Rakovchik YGorry SDelnay NRobinson LMorgan ESheets RMellins EDRamanan AVSchmitt ERobinson AKovalick LNguyen AFuller JShishov MfalseInterleukin (IL)-1/IL-6-Inhibitor-Associated Drug Reaction With Eosinophilia and Systemic Symptoms (DReSS) in Systemic Inflammatory Illnesses.<h4>Background</h4>After introducing IL-1/IL-6 inhibitors, some patients with Still and Still-like disease developed unusual, often fatal, pulmonary disease. This complication was associated with scoring as DReSS (drug reaction with eosinophilia and systemic symptoms) implicating these inhibitors, although DReSS can be difficult to recognize in the setting of systemic inflammatory disease.<h4>Objective</h4>To facilitate recognition of IL-1/IL-6 inhibitor-DReSS in systemic inflammatory illnesses (Still/Still-like) by looking at timing and reaction-associated features. We evaluated outcomes of stopping or not stopping IL-1/IL-6 inhibitors after DReSS reaction began.<h4>Methods</h4>In an international study collaborating primarily with pediatric specialists, we characterized features of 89 dr2024-01-01T00:00:00Z2024 Nov2026-06-05T07:28:03.174Z2026-05-14T03:12:44.125ZS-EPMC115605923900272210.1016/j.jaip.2024.07.002