{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li G"],"funding":["NHLBI NIH HHS","National Institutes of Health","National Heart Lung and Blood Institute"],"pagination":["109198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11560667"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["182"],"pubmed_abstract":["The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning the balance between RBC formation (erythropoiesis) and removal. The retention and elimination of RBCs occur predominantly in the open circulation of the spleen, where RBCs must cross submicron-wide inter-endothelial slits (IES). Several experimental and computational studies have illustrated the role of IES in filtrating the biomechanically and morphologically altered RBCs based on a rigid wall assumption. However, these studies also reported that when the size of IES is close to the lower end of clinically observed sizes (less than 0.5 μm), an unphysiologically large pressure difference across the IES is required to drive the passage of normal RBCs, sparking debates on the feasibility of the rigid wal"],"journal":["Computers in biology and medicine"],"pubmed_title":["Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics."],"pmcid":["PMC11560667"],"funding_grant_id":["R01HL154150","R01 HL154150"],"pubmed_authors":["Li G","Li H","Li X","Ndour PA","Karniadakis GE","Buffet PA","Dao M","MacDonald I","Franco M"],"additional_accession":[]},"is_claimable":false,"name":"Red blood cell passage through deformable interendothelial slits in the spleen: Insights into splenic filtration and hemodynamics.","description":"The spleen constantly clears altered red blood cells (RBCs) from the circulation, tuning the balance between RBC formation (erythropoiesis) and removal. The retention and elimination of RBCs occur predominantly in the open circulation of the spleen, where RBCs must cross submicron-wide inter-endothelial slits (IES). Several experimental and computational studies have illustrated the role of IES in filtrating the biomechanically and morphologically altered RBCs based on a rigid wall assumption. However, these studies also reported that when the size of IES is close to the lower end of clinically observed sizes (less than 0.5 μm), an unphysiologically large pressure difference across the IES is required to drive the passage of normal RBCs, sparking debates on the feasibility of the rigid wal","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T07:16:46.912Z","creation":"2026-05-14T03:09:00.161Z"},"accession":"S-EPMC11560667","cross_references":{"pubmed":["39341110"],"doi":["10.1016/j.compbiomed.2024.109198"]}}