{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang J"],"funding":["National Natural Science Foundation of China"],"pagination":["274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11562302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Objective</h4>The relationship between blood glucose levels and osteoarthritis (OA) is unclear. This study aimed to investigate the genetic causal relationship between blood glucose-related traits and OA.<h4>Methods</h4>We first performed univariate Mendelian randomization (UVMR) analyses using published genome-wide association study (GWAS) datasets with fasting glucose (FG), 2 h-glucose post-challenge glucose (2hGlu), and glycosylated hemoglobin (HbA1c) as exposures, and hip osteoarthritis (HOA) and knee osteoarthritis (KOA) as outcomes; then, we performed inverse analyses of them. We used Inverse-variance weighted (IVW) analysis as the primary analysis, and sensitivity analyses were performed. Moreover, we performed multivariate Mendelian randomization (MVMR) to estimate the independ"],"journal":["Diabetology & metabolic syndrome"],"pubmed_title":["Is there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study."],"pmcid":["PMC11562302"],"funding_grant_id":["No. 82072432"],"pubmed_authors":["Xu K","Xu P","Yang M","Peng L","Feng R","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Is there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study.","description":"<h4>Objective</h4>The relationship between blood glucose levels and osteoarthritis (OA) is unclear. This study aimed to investigate the genetic causal relationship between blood glucose-related traits and OA.<h4>Methods</h4>We first performed univariate Mendelian randomization (UVMR) analyses using published genome-wide association study (GWAS) datasets with fasting glucose (FG), 2 h-glucose post-challenge glucose (2hGlu), and glycosylated hemoglobin (HbA1c) as exposures, and hip osteoarthritis (HOA) and knee osteoarthritis (KOA) as outcomes; then, we performed inverse analyses of them. We used Inverse-variance weighted (IVW) analysis as the primary analysis, and sensitivity analyses were performed. Moreover, we performed multivariate Mendelian randomization (MVMR) to estimate the independ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2025-04-04T14:43:51.072Z","creation":"2025-04-04T14:43:51.072Z"},"accession":"S-EPMC11562302","cross_references":{"pubmed":["39543708"],"doi":["10.1186/s13098-024-01517-3"]}}