biostudies-literatureWang JNational Natural Science Foundation of China274https://www.ebi.ac.uk/biostudies/studies/S-EPMC11562302biostudies-literatureUnknown16(1)<h4>Objective</h4>The relationship between blood glucose levels and osteoarthritis (OA) is unclear. This study aimed to investigate the genetic causal relationship between blood glucose-related traits and OA.<h4>Methods</h4>We first performed univariate Mendelian randomization (UVMR) analyses using published genome-wide association study (GWAS) datasets with fasting glucose (FG), 2 h-glucose post-challenge glucose (2hGlu), and glycosylated hemoglobin (HbA1c) as exposures, and hip osteoarthritis (HOA) and knee osteoarthritis (KOA) as outcomes; then, we performed inverse analyses of them. We used Inverse-variance weighted (IVW) analysis as the primary analysis, and sensitivity analyses were performed. Moreover, we performed multivariate Mendelian randomization (MVMR) to estimate the independDiabetology & metabolic syndromeIs there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study.PMC11562302No. 82072432Xu KXu PYang MPeng LFeng RWang JfalseIs there a genetic relationship between blood glucose and osteoarthritis? A mendelian randomization study.<h4>Objective</h4>The relationship between blood glucose levels and osteoarthritis (OA) is unclear. This study aimed to investigate the genetic causal relationship between blood glucose-related traits and OA.<h4>Methods</h4>We first performed univariate Mendelian randomization (UVMR) analyses using published genome-wide association study (GWAS) datasets with fasting glucose (FG), 2 h-glucose post-challenge glucose (2hGlu), and glycosylated hemoglobin (HbA1c) as exposures, and hip osteoarthritis (HOA) and knee osteoarthritis (KOA) as outcomes; then, we performed inverse analyses of them. We used Inverse-variance weighted (IVW) analysis as the primary analysis, and sensitivity analyses were performed. Moreover, we performed multivariate Mendelian randomization (MVMR) to estimate the independ2024-01-01T00:00:00Z2024 Nov2025-04-04T14:43:51.072Z2025-04-04T14:43:51.072ZS-EPMC115623023954370810.1186/s13098-024-01517-3