{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Zaman Z"],"funding":["This work is supported by the Alzheimer’s disease Research Program startup fund to Dr. Sharoar from the Corewell Health East (formally Beaumont Health)."],"pubmed_abstract":["Background
The unprecedented increase in the older population and ever-increasing incidence of dementia are leading to a \"silver tsunami\" in upcoming decades. To combat multimorbidity and maintain daily activities, elderly people face a high prevalence of polypharmacy. However, how these medications affect dementia-related pathology, such as Alzheimer's β-amyloid (Aβ) fibrils formation, remains unknown. In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Aβ fibrils formation.Methods
Study subjects (≥ 65 years) were recruited from an academic geriatric practice t"],"journal":["BMC neurology"],"pagination":["445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11562802"],"repository":["biostudies-literature"],"pubmed_title":["Highly prevalent geriatric medications and their effect on β-amyloid fibril formation."],"pmcid":["PMC11562802"],"pubmed_authors":["Islam R","Graham S","Osentoski T","Zaman Z","Sharoar MG","Falki V","Koganti B"],"additional_accession":[]},"is_claimable":false,"name":"Highly prevalent geriatric medications and their effect on β-amyloid fibril formation.","description":"Background
The unprecedented increase in the older population and ever-increasing incidence of dementia are leading to a \"silver tsunami\" in upcoming decades. To combat multimorbidity and maintain daily activities, elderly people face a high prevalence of polypharmacy. However, how these medications affect dementia-related pathology, such as Alzheimer's β-amyloid (Aβ) fibrils formation, remains unknown. In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Aβ fibrils formation.Methods
Study subjects (≥ 65 years) were recruited from an academic geriatric practice t","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T22:56:15.065Z","creation":"2025-04-06T01:40:22.414Z"},"accession":"S-EPMC11562802","cross_references":{"pubmed":["39543530"],"doi":["10.1186/s12883-024-03930-7"]}}