biostudies-literatureUnknown24(1)Zaman ZThis work is supported by the Alzheimer’s disease Research Program startup fund to Dr. Sharoar from the Corewell Health East (formally Beaumont Health).<h4>Background</h4>The unprecedented increase in the older population and ever-increasing incidence of dementia are leading to a "silver tsunami" in upcoming decades. To combat multimorbidity and maintain daily activities, elderly people face a high prevalence of polypharmacy. However, how these medications affect dementia-related pathology, such as Alzheimer's β-amyloid (Aβ) fibrils formation, remains unknown. In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Aβ fibrils formation.<h4>Methods</h4>Study subjects (≥ 65 years) were recruited from an academic geriatric practice tBMC neurology445https://www.ebi.ac.uk/biostudies/studies/S-EPMC11562802biostudies-literatureHighly prevalent geriatric medications and their effect on β-amyloid fibril formation.PMC11562802Islam RGraham SOsentoski TZaman ZSharoar MGFalki VKoganti BfalseHighly prevalent geriatric medications and their effect on β-amyloid fibril formation.<h4>Background</h4>The unprecedented increase in the older population and ever-increasing incidence of dementia are leading to a "silver tsunami" in upcoming decades. To combat multimorbidity and maintain daily activities, elderly people face a high prevalence of polypharmacy. However, how these medications affect dementia-related pathology, such as Alzheimer's β-amyloid (Aβ) fibrils formation, remains unknown. In the present study, we aimed to analyze the medication profiles of Alzheimer's disease (AD; n = 124), mild cognitive impairment (MCI; n = 114), and non-demented (ND; n = 228) patients to identify highly prevalent drugs and to determine the effects of those drugs on Aβ fibrils formation.<h4>Methods</h4>Study subjects (≥ 65 years) were recruited from an academic geriatric practice t2024-01-01T00:00:00Z2024 Nov2026-07-16T22:56:15.065Z2025-04-06T01:40:22.414ZS-EPMC115628023954353010.1186/s12883-024-03930-7