{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Sun C"],"pubmed_abstract":["<i>Candida albicans</i>, a common commensal and opportunistic fungal pathogen in humans, can occasionally progress to disseminated candidiasis which is a serious condition with a high morbidity and fatality rate. The emergence of drug-resistant fungal strains compels us to look for an efficient treatment solution. Our earlier studies have demonstrated that the unique antimicrobial peptide AMP-17 from <i>Musca domestica</i> has a strong antifungal impact on <i>C. albicans in vitro</i>. Here, we verified the therapeutic effects of AMP-17 on systemic candidiasis <i>in vivo</i> and the peptide interacts with fluconazole, a common antifungal medication, to treat systemic candidiasis. In the disseminated candidiasis model of <i>Galleria mellonella</i> and mice challenged with <i>C. albicans</i>,"],"journal":["Frontiers in microbiology"],"pagination":["1480808"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11564183"],"repository":["biostudies-literature"],"pubmed_title":["Antimicrobial peptide AMP-17 induces protection against systemic candidiasis and interacts synergistically with fluconazole against &lt;i&gt;Candida albicans&lt;/i&gt; biofilm."],"pmcid":["PMC11564183"],"pubmed_authors":["Tian Z","Yang L","Zhu L","Sun C","Guo G","Huang M","Jiao Z","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Antimicrobial peptide AMP-17 induces protection against systemic candidiasis and interacts synergistically with fluconazole against &lt;i&gt;Candida albicans&lt;/i&gt; biofilm.","description":"<i>Candida albicans</i>, a common commensal and opportunistic fungal pathogen in humans, can occasionally progress to disseminated candidiasis which is a serious condition with a high morbidity and fatality rate. The emergence of drug-resistant fungal strains compels us to look for an efficient treatment solution. Our earlier studies have demonstrated that the unique antimicrobial peptide AMP-17 from <i>Musca domestica</i> has a strong antifungal impact on <i>C. albicans in vitro</i>. Here, we verified the therapeutic effects of AMP-17 on systemic candidiasis <i>in vivo</i> and the peptide interacts with fluconazole, a common antifungal medication, to treat systemic candidiasis. In the disseminated candidiasis model of <i>Galleria mellonella</i> and mice challenged with <i>C. albicans</i>,","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-18T12:50:25.556Z","creation":"2025-04-06T22:13:18.737Z"},"accession":"S-EPMC11564183","cross_references":{"pubmed":["39552641"],"doi":["10.3389/fmicb.2024.1480808"]}}