biostudies-literatureUnknown15Sun C<i>Candida albicans</i>, a common commensal and opportunistic fungal pathogen in humans, can occasionally progress to disseminated candidiasis which is a serious condition with a high morbidity and fatality rate. The emergence of drug-resistant fungal strains compels us to look for an efficient treatment solution. Our earlier studies have demonstrated that the unique antimicrobial peptide AMP-17 from <i>Musca domestica</i> has a strong antifungal impact on <i>C. albicans in vitro</i>. Here, we verified the therapeutic effects of AMP-17 on systemic candidiasis <i>in vivo</i> and the peptide interacts with fluconazole, a common antifungal medication, to treat systemic candidiasis. In the disseminated candidiasis model of <i>Galleria mellonella</i> and mice challenged with <i>C. albicans</i>,Frontiers in microbiology1480808https://www.ebi.ac.uk/biostudies/studies/S-EPMC11564183biostudies-literatureAntimicrobial peptide AMP-17 induces protection against systemic candidiasis and interacts synergistically with fluconazole against <i>Candida albicans</i> biofilm.PMC11564183Tian ZYang LZhu LSun CGuo GHuang MJiao ZPeng JfalseAntimicrobial peptide AMP-17 induces protection against systemic candidiasis and interacts synergistically with fluconazole against <i>Candida albicans</i> biofilm.<i>Candida albicans</i>, a common commensal and opportunistic fungal pathogen in humans, can occasionally progress to disseminated candidiasis which is a serious condition with a high morbidity and fatality rate. The emergence of drug-resistant fungal strains compels us to look for an efficient treatment solution. Our earlier studies have demonstrated that the unique antimicrobial peptide AMP-17 from <i>Musca domestica</i> has a strong antifungal impact on <i>C. albicans in vitro</i>. Here, we verified the therapeutic effects of AMP-17 on systemic candidiasis <i>in vivo</i> and the peptide interacts with fluconazole, a common antifungal medication, to treat systemic candidiasis. In the disseminated candidiasis model of <i>Galleria mellonella</i> and mice challenged with <i>C. albicans</i>,2024-01-01T00:00:00Z20242025-04-18T12:50:25.556Z2025-04-06T22:13:18.737ZS-EPMC115641833955264110.3389/fmicb.2024.1480808