biostudies-literatureHinson HENINDS NIH HHS2349-2361https://www.ebi.ac.uk/biostudies/studies/S-EPMC11564838biostudies-literatureUnknown41(19-20)Progression of intracranial hemorrhage is a common, potentially devastating complication after moderate/severe traumatic brain injury (TBI). Clinicians have few tools to predict which patients with traumatic intracranial hemorrhage on their initial head computed tomography (hCT) scan will progress. The objective of this investigation was to identify clinical, imaging, and/or protein biomarkers associated with progression of intracranial hemorrhage (PICH) after moderate/severe TBI and to create an accurate predictive model of PICH based on clinical features available at presentation. We analyzed a subset of subjects from the phase II double-blind, multi-center, randomized "Prehospital Tranexamic Acid Use for TBI" trial. This subset was limited to the placebo arm of the parent trial with eviJournal of neurotraumaPredicting Progression of Intracranial Hemorrhage in the Prehospital TXA for TBI Trial.PMC11564838K23 NS110828Radabaugh HLSchreiber MRowell SFerguson ARFukuda THinson HEPollock JLi NfalsePredicting Progression of Intracranial Hemorrhage in the Prehospital TXA for TBI Trial.Progression of intracranial hemorrhage is a common, potentially devastating complication after moderate/severe traumatic brain injury (TBI). Clinicians have few tools to predict which patients with traumatic intracranial hemorrhage on their initial head computed tomography (hCT) scan will progress. The objective of this investigation was to identify clinical, imaging, and/or protein biomarkers associated with progression of intracranial hemorrhage (PICH) after moderate/severe TBI and to create an accurate predictive model of PICH based on clinical features available at presentation. We analyzed a subset of subjects from the phase II double-blind, multi-center, randomized "Prehospital Tranexamic Acid Use for TBI" trial. This subset was limited to the placebo arm of the parent trial with evi2024-01-01T00:00:00Z2024 Oct2026-06-04T14:39:40.295Z2026-05-10T03:11:24.808ZS-EPMC115648383861871310.1089/neu.2023.0626