{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou Y"],"funding":["Excellent Young Scientists Fund","Research Grants Council, University Grants Committee","Research Grants Council, University Grants Committee ()","National Natural Science Foundation of China","Excellent Young Scientists Fund (Young Scientists Fund)","China Postdoctoral Science Foundation","National Natural Science Foundation of China (NSFC)","China Postdoctoral Science Foundation (China Postdoctoral Foundation Project)"],"pagination":["3834-3847"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565167"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(22)"],"pubmed_abstract":["A variety of state-of-the-art nanovaccines (NV) combined with immunotherapies have recently been developed to treat malignant tumors, showing promising results. However, immunosuppression in the tumor microenvironment (TME) restrains cytotoxic T-cell infiltration and limits the efficacy of immunotherapies in solid tumors. Therefore, tactics for enhancing antigen cross-presentation and reshaping the TME need to be explored to enhance the activity of NVs. Here, we developed photo-enhanceable inflammasome-activating NVs (PIN) to achieve precise in situ delivery of a tumor antigen and a hydrophobic small molecule activating the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome (NLRP3) pathway. Near-infrared light irradiation prom"],"journal":["Cancer research"],"pubmed_title":["Precise In Situ Delivery of a Photo-Enhanceable Inflammasome-Activating Nanovaccine Activates Anticancer Immunity."],"pmcid":["PMC11565167"],"funding_grant_id":["2023M734036","82222903","2022TQ0388","T12-703/19R"],"pubmed_authors":["Liu J","Wu M","Chen K","Ding T","Pang L","Wang W","Zhou Y","Man K"],"additional_accession":[]},"is_claimable":false,"name":"Precise In Situ Delivery of a Photo-Enhanceable Inflammasome-Activating Nanovaccine Activates Anticancer Immunity.","description":"A variety of state-of-the-art nanovaccines (NV) combined with immunotherapies have recently been developed to treat malignant tumors, showing promising results. However, immunosuppression in the tumor microenvironment (TME) restrains cytotoxic T-cell infiltration and limits the efficacy of immunotherapies in solid tumors. Therefore, tactics for enhancing antigen cross-presentation and reshaping the TME need to be explored to enhance the activity of NVs. Here, we developed photo-enhanceable inflammasome-activating NVs (PIN) to achieve precise in situ delivery of a tumor antigen and a hydrophobic small molecule activating the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 inflammasome (NLRP3) pathway. Near-infrared light irradiation prom","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-02T03:37:07.657Z","creation":"2025-04-04T12:01:44.734Z"},"accession":"S-EPMC11565167","cross_references":{"pubmed":["39288074"],"doi":["10.1158/0008-5472.CAN-24-0220"]}}