{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Piechatzek A"],"funding":["University of Adelaide"],"pagination":["6856-6871"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(21)"],"pubmed_abstract":["Optimal stomatal regulation is important for plant adaptation to changing environmental conditions and for maintaining crop yield. The guard cell signal γ-aminobutyric acid (GABA) is produced from glutamate by glutamate decarboxylase (GAD) during a reaction that generates CO2 as a by-product. Here, we investigated a putative connection between GABA signalling and the more clearly defined CO2 signalling pathway in guard cells. The GABA-deficient mutant Arabidopsis lines gad2-1, gad2-2, and gad1/2/4/5 were examined for stomatal sensitivity to various CO2 concentrations. Our findings show a phenotypical discrepancy between the allelic mutant lines gad2-1 and gad2-2-a weakened CO2 response in gad2-1 (GABI_474_E05) in contrast to a wild-type response in gad2-2 (SALK_028819) and gad1/2/4/5. Thro"],"journal":["Journal of experimental botany"],"pubmed_title":["GABA does not regulate stomatal CO2 signalling in Arabidopsis."],"pmcid":["PMC11565201"],"funding_grant_id":["CE230100015"],"pubmed_authors":["Ache P","Dittrich M","Herrmann J","Feng X","Muller T","Hurgobin B","Piechatzek A","Kromdijk J","Lewsey M","Sai N","Hedrich R","Xu B","Yi C","Gilliham M"],"additional_accession":[]},"is_claimable":false,"name":"GABA does not regulate stomatal CO2 signalling in Arabidopsis.","description":"Optimal stomatal regulation is important for plant adaptation to changing environmental conditions and for maintaining crop yield. The guard cell signal γ-aminobutyric acid (GABA) is produced from glutamate by glutamate decarboxylase (GAD) during a reaction that generates CO2 as a by-product. Here, we investigated a putative connection between GABA signalling and the more clearly defined CO2 signalling pathway in guard cells. The GABA-deficient mutant Arabidopsis lines gad2-1, gad2-2, and gad1/2/4/5 were examined for stomatal sensitivity to various CO2 concentrations. Our findings show a phenotypical discrepancy between the allelic mutant lines gad2-1 and gad2-2-a weakened CO2 response in gad2-1 (GABI_474_E05) in contrast to a wild-type response in gad2-2 (SALK_028819) and gad1/2/4/5. Thro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T21:47:33.931Z","creation":"2025-04-05T18:41:31.844Z"},"accession":"S-EPMC11565201","cross_references":{"pubmed":["38628155"],"doi":["10.1093/jxb/erae168"]}}