{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chang-Wolf JM"],"funding":["NEI NIH HHS"],"pagination":["7-14"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565374"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["143(1)"],"pubmed_abstract":["<h4>Importance</h4>Primary open-angle glaucoma (POAG) polygenic risk scores (PRSs) continue to be evaluated in primarily European-ancestry populations despite higher prevalence and worse outcomes in African-ancestry populations.<h4>Objective</h4>To evaluate how established POAG PRSs perform in African-ancestry samples from the Genetics in Glaucoma Patients of African Descent (GIGA), Genetics of Glaucoma in Individuals of African Descent (GGLAD), and Million Veteran Program (MVP) datasets and compare these with European-ancestry samples.<h4>Design, setting, and participants</h4>This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US. Included were individuals of African descent from South Africa and Tanzania from the G"],"journal":["JAMA ophthalmology"],"pubmed_title":["Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent."],"pmcid":["PMC11565374"],"funding_grant_id":["R21 EY028671","R01 EY033829","R01 EY032960","P30 EY031631","R21 EY033961"],"pubmed_authors":["Akafo S","Bowden DW","Mullins RF","Cunningham F","Novin M","Colling C","Moroi SE","Maus L","Carfagno G","Brewer J","Goodson W","Napo A","Kushner R","Hauser MA","Tharp DF","Leon T","Ntomoka C","Kelsoe J","Tsao P","Loos RJ","Sorensen LH","Sison C","Qin XJ","Grainger M","Araeva N","Girkin CA","Oliveira MB","Do N","Gaziano M","Villarreal G","Jain V","Pasquale LR","Acheampong S","Devroy S","Miller K","Sanywia AJ","Antonelli M","Steinhauer S","Nguyen XM","DeLisi LE","Harley J","Vasconcellos JPC","Miller P","Zhao Z","Kinzy TG","Sklar P","O Leary T","Schwartz BL","Hammer MB","Kelly E","Marder SR","Muly EC","Rybalsky 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Veteran Program (MVP) datasets and compare these with European-ancestry samples.<h4>Design, setting, and participants</h4>This was a multicenter, cross-sectional study of POAG cases and controls from Tanzania, South Africa, Nigeria, Ghana, and the US. Included were individuals of African descent from South Africa and Tanzania from the G","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Jan","modification":"2026-06-05T12:35:57.037Z","creation":"2026-05-16T03:13:02.604Z"},"accession":"S-EPMC11565374","cross_references":{"pubmed":["39541127"],"doi":["10.1001/jamaophthalmol.2024.4784"]}}