{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(49)"],"submitter":["Shah ZA"],"pubmed_abstract":["Fungal metabolites are known for their broad therapeutic effects. In this context, the fungal strain of <i>Aspergillus ficuum</i> (FCBP-DNA-1266) was examined for its secondary metabolites and <i>in vivo</i> activities. This led to the isolation of naphtho-gamma-pyrone (aurasperone B) and a sterol (ergosterol), characterized using advanced spectroscopic techniques such as <sup>1</sup>H NMR and <sup>13</sup>C NMR. The isolated metabolites were evaluated for their <i>in vivo</i> anti-inflammatory and analgesic activities utilizing an animal model. The study showed that both metabolites have significant pharmacological effects (<i>P</i> ≤ 0.05) in a dose-dependent manner. In addition, <i>in silico</i> analysis was employed to aid the <i>in vivo</i> anti-inflammatory activity and the molecular docking results were in agreement with the experimental findings. For the first time, we present the pharmacological activities and 2D NMR of aurasperone B, which will shed light on the bioactive potential of secondary metabolites of <i>Aspergillus ficuum</i>."],"journal":["RSC advances"],"pagination":["36527-36537"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565488"],"repository":["biostudies-literature"],"pubmed_title":["Isolation, characterization and pharmacological investigations of secondary metabolites from <i>Aspergillus ficuum via</i> experimental and computational techniques."],"pmcid":["PMC11565488"],"pubmed_authors":["Khan K","Shah ZA","Shah T","Khan A","Ahmad N"],"additional_accession":[]},"is_claimable":false,"name":"Isolation, characterization and pharmacological investigations of secondary metabolites from <i>Aspergillus ficuum via</i> experimental and computational techniques.","description":"Fungal metabolites are known for their broad therapeutic effects. In this context, the fungal strain of <i>Aspergillus ficuum</i> (FCBP-DNA-1266) was examined for its secondary metabolites and <i>in vivo</i> activities. This led to the isolation of naphtho-gamma-pyrone (aurasperone B) and a sterol (ergosterol), characterized using advanced spectroscopic techniques such as <sup>1</sup>H NMR and <sup>13</sup>C NMR. The isolated metabolites were evaluated for their <i>in vivo</i> anti-inflammatory and analgesic activities utilizing an animal model. The study showed that both metabolites have significant pharmacological effects (<i>P</i> ≤ 0.05) in a dose-dependent manner. In addition, <i>in silico</i> analysis was employed to aid the <i>in vivo</i> anti-inflammatory activity and the molecular docking results were in agreement with the experimental findings. For the first time, we present the pharmacological activities and 2D NMR of aurasperone B, which will shed light on the bioactive potential of secondary metabolites of <i>Aspergillus ficuum</i>.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-02T03:36:04.997Z","creation":"2025-04-04T12:01:14.879Z"},"accession":"S-EPMC11565488","cross_references":{"pubmed":["39553270"],"doi":["10.1039/d4ra03674c"]}}