{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["He Z"],"funding":["NIAMS NIH HHS"],"pubmed_abstract":["Some autoimmune diseases, including rheumatoid arthritis (RA), are preceded by a critical subclinical phase of disease activity. Proactive clinical management is hampered by a lack of biological understanding of this subclinical 'at-risk' state and the changes underlying disease development. In a cross-sectional and longitudinal multi-omics study of peripheral immunity in the autoantibody-positive at-risk for RA period, we identified systemic inflammation, proinflammatory-skewed B cells, expanded Tfh17-like cells, epigenetic bias in naive T cells, TNF+IL1B+ monocytes resembling a synovial macrophage population, and CD4 T cell transcriptional features resembling those suppressed by abatacept (CTLA4-Ig) in RA patients. Our findings characterize pathogenesis prior to clinical diagnosis and su"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.25.620344"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565773"],"repository":["biostudies-literature"],"pubmed_title":["Systemic inflammation and lymphocyte activation precede rheumatoid arthritis."],"pmcid":["PMC11565773"],"funding_grant_id":["P30 AR079369"],"pubmed_authors":["Zhang F","Asamoah AG","Mettey RR","Zaim SR","Peng T","Graybuck LT","Reading J","Li XJ","Swanson EG","Parthasarathy V","Garber J","Ochoa A","Collora CE","Genge PC","Kuan EL","Feser ML","Boyle DL","Wang W","Venkatesan P","Firestein GS","Gillespie MA","Roll CR","Okada LY","Krishnan U","Heubeck AT","Fleischer CL","Li R","Goldrath AW","Westermann A","LaFrance CM","Tsaltskan V","Savage AK","Takada H","He Z","Hattel BC","Holers VM","Becker LA","Buckner JH","Gong Q","Stuckey TJ","Ravisankar P","He YD","Speake C","Thai T","Striebich CC","Torgerson TR","Pedrick C","Demoruelle MK","Pebworth MP","Barzideh S","Gustafson CE","Hernandez V","Kuhn KA","Trieu N","Seifert JA","Skene PJ","Deane KD","Siedschlag MD","Musgrove B","Thomson ZJ","Arishi NA","Nguyen K","Weiss MDA","Bennett CE","Bumol TF","Dornisch EM","Lazaro L","Tran NTT","Bemis EA","Glass MC","Lord C","Moss L","Kawelo EK","Lee KJ","Criley MAL","Phalen CG"],"additional_accession":[]},"is_claimable":false,"name":"Systemic inflammation and lymphocyte activation precede rheumatoid arthritis.","description":"Some autoimmune diseases, including rheumatoid arthritis (RA), are preceded by a critical subclinical phase of disease activity. Proactive clinical management is hampered by a lack of biological understanding of this subclinical 'at-risk' state and the changes underlying disease development. In a cross-sectional and longitudinal multi-omics study of peripheral immunity in the autoantibody-positive at-risk for RA period, we identified systemic inflammation, proinflammatory-skewed B cells, expanded Tfh17-like cells, epigenetic bias in naive T cells, TNF+IL1B+ monocytes resembling a synovial macrophage population, and CD4 T cell transcriptional features resembling those suppressed by abatacept (CTLA4-Ig) in RA patients. Our findings characterize pathogenesis prior to clinical diagnosis and su","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-05-28T03:25:37.563Z","creation":"2025-04-04T02:47:47.154Z"},"accession":"S-EPMC11565773","cross_references":{"pubmed":["39554042"],"doi":["10.1101/2024.10.25.620344"]}}