{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mukherjee SD"],"funding":["NIDDK NIH HHS"],"pubmed_abstract":["Decades of research have made clear that host-associated microbiomes touch all facets of health. However, effective therapies that target the microbiome have been elusive given its inherent complexity. Here, we experimentally examined diet-microbe-host interactions through a complex systems framework, centered on dietary oxalate. Using multiple, independent molecular, animal, and <i>in vitro</i> experimental models, we found that microbiome composition influenced multiple oxalate-microbe-host interfaces. Importantly, administration of the oxalate-degrading specialist, <i>Oxalobacter formigenes,</i> was only effective against a poor oxalate-degrading microbiota background and gives critical new insights into why clinical intervention trials with this species exhibit variable outcomes. Data "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.10.28.620613"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565779"],"repository":["biostudies-literature"],"pubmed_title":["Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria."],"pmcid":["PMC11565779"],"funding_grant_id":["R01 DK121689"],"pubmed_authors":["Dearing D","Batagello CA","Agudelo J","Mukherjee SD","Zampini A","Nguyen A","Monga M","Adler A","Orr T","Miller AW","Suryavanshi M"],"additional_accession":[]},"is_claimable":false,"name":"Complex system modelling reveals oxalate homeostasis is driven by diverse oxalate-degrading bacteria.","description":"Decades of research have made clear that host-associated microbiomes touch all facets of health. However, effective therapies that target the microbiome have been elusive given its inherent complexity. Here, we experimentally examined diet-microbe-host interactions through a complex systems framework, centered on dietary oxalate. Using multiple, independent molecular, animal, and <i>in vitro</i> experimental models, we found that microbiome composition influenced multiple oxalate-microbe-host interfaces. Importantly, administration of the oxalate-degrading specialist, <i>Oxalobacter formigenes,</i> was only effective against a poor oxalate-degrading microbiota background and gives critical new insights into why clinical intervention trials with this species exhibit variable outcomes. Data ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Feb","modification":"2025-07-10T03:08:50.898Z","creation":"2025-04-06T03:20:55.457Z"},"accession":"S-EPMC11565779","cross_references":{"pubmed":["39553961"],"doi":["10.1101/2024.10.28.620613"]}}