biostudies-literatureAllen SWCenters for Disease Control and PreventionNIAID NIH HHSNational Institutes of HealthNIH HHSCDC HHSe1031-e1038https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565896biostudies-literatureUnknown230(5)There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, but it was unclear whether there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately before the epidemic. We found that 69 of 2938 sampled individuals (2.4%) were seropositive to CHIKV. Seropositivity to dengue virus (adjusted odds ratio, 3.13 [95% confidence interval, 1.86-5.27]), male sex (0.59 [.36-.99]), and community presence of Aedes aegypti mosquitoes (1.80 [1.05-3.0]7) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% confidence interval, 4.89-5.08) million people had been previously The Journal of infectious diseasesResults of a Nationally Representative Seroprevalence Survey of Chikungunya Virus in Bangladesh.PMC11565896U01 AI151801U01AI151801R24 AI120942Allen SWPaul KKRahman MZAlam MSSmull TPaul RRahman MGurley ESSalje HRibeiro Dos Santos GWeaver SCAl-Amin HMVanhomwegen JLee KHfalseResults of a Nationally Representative Seroprevalence Survey of Chikungunya Virus in Bangladesh.There is an increasing global burden from chikungunya virus (CHIKV). Bangladesh reported a major epidemic in 2017, but it was unclear whether there had been prior widespread transmission. We conducted a nationally representative seroprevalence survey in 70 randomly selected communities immediately before the epidemic. We found that 69 of 2938 sampled individuals (2.4%) were seropositive to CHIKV. Seropositivity to dengue virus (adjusted odds ratio, 3.13 [95% confidence interval, 1.86-5.27]), male sex (0.59 [.36-.99]), and community presence of Aedes aegypti mosquitoes (1.80 [1.05-3.0]7) were significantly associated with CHIKV seropositivity. Using a spatial prediction model, we estimated that across the country, 4.99 (95% confidence interval, 4.89-5.08) million people had been previously 2024-01-01T00:00:00Z2024 Nov2026-07-16T22:37:59.048Z2025-04-05T18:41:27.892ZS-EPMC115658963894273110.1093/infdis/jiae335