biostudies-literatureUnknownMitchell WNIBIB NIH HHSNIA NIH HHSNIAMS NIH HHSAging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated with mitochondrial dysfunction across both clinical and pre-clinical models. ELAM is proposed to restore mitochondrial bioenergetic function by stabilizing inner membrane structure and increasing oxidative phosphorylation coupling and efficiency. Although ELAM treatment effectively attenuates physiological declines in multiple tissues in rodent aging models, it remains unclear whether these functional improvements correlate with favorable changes in molecular biomarkers of aging. Herein, we investigated the impact of 8-week ELAbioRxiv : the preprint server for biology2024.10.30.620676https://www.ebi.ac.uk/biostudies/studies/S-EPMC11565897biostudies-literatureThe mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.PMC11565897P01 AG047200R01 AG078279T32 AG066574T32 EB016652R56 AG078279P01 AG001751R01 AG065403P30 AR074990Pharaoh GGladyshev VNTyshkovskiy AMarcinek DJMitchell WCampbell MfalseThe mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.Aging-related decreases in cardiac and skeletal muscle function are strongly associated with various comorbidities. Elamipretide (ELAM), a novel mitochondrial-targeted peptide, has demonstrated broad therapeutic efficacy in ameliorating disease conditions associated with mitochondrial dysfunction across both clinical and pre-clinical models. ELAM is proposed to restore mitochondrial bioenergetic function by stabilizing inner membrane structure and increasing oxidative phosphorylation coupling and efficiency. Although ELAM treatment effectively attenuates physiological declines in multiple tissues in rodent aging models, it remains unclear whether these functional improvements correlate with favorable changes in molecular biomarkers of aging. Herein, we investigated the impact of 8-week ELA2024-01-01T00:00:00Z2024 Oct2025-04-04T02:46:47.136Z2025-04-04T02:46:47.136ZS-EPMC115658973955409910.1101/2024.10.30.620676