{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hwang SH"],"funding":["National research foundation (KR)","National research foundation"],"pagination":["137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11566202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4<sup>+</sup> tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA desaturase (SCD) increased by treatment with cancer-associated fibroblast (CAF) supernatant in CD4<sup>+</sup> T cells on their subset differentiation and activity of CD8<sup>+</sup> T cells.<h4>Results</h4>In our study, we observed that CD4<sup>+</sup> TILs had higher lipid droplet content than CD4<sup>+</sup> splenic T cells. In tumor tissue, CAF-derived supernatant provided fatty acids to CD4<sup>+</sup> TILs, which increased the expression of SCD and oleic acid (OA) content. Incre"],"journal":["Cell & bioscience"],"pubmed_title":["Stearoyl-CoA desaturase in CD4<sup>+</sup> T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8<sup>+</sup> T cells."],"pmcid":["PMC11566202"],"funding_grant_id":["RS-2023-00249667","2020R1A2C1010215","RS-2024-00351740"],"pubmed_authors":["Yang Y","Hwang SH","Kim Y","Jung JH","Kim JW"],"additional_accession":[]},"is_claimable":false,"name":"Stearoyl-CoA desaturase in CD4<sup>+</sup> T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8<sup>+</sup> T cells.","description":"<h4>Background</h4>Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4<sup>+</sup> tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA desaturase (SCD) increased by treatment with cancer-associated fibroblast (CAF) supernatant in CD4<sup>+</sup> T cells on their subset differentiation and activity of CD8<sup>+</sup> T cells.<h4>Results</h4>In our study, we observed that CD4<sup>+</sup> TILs had higher lipid droplet content than CD4<sup>+</sup> splenic T cells. In tumor tissue, CAF-derived supernatant provided fatty acids to CD4<sup>+</sup> TILs, which increased the expression of SCD and oleic acid (OA) content. Incre","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T22:37:25.546Z","creation":"2025-04-06T01:39:47.349Z"},"accession":"S-EPMC11566202","cross_references":{"pubmed":["39543650"],"doi":["10.1186/s13578-024-01308-3"]}}