biostudies-literatureHwang SHNational research foundation (KR)National research foundation137https://www.ebi.ac.uk/biostudies/studies/S-EPMC11566202biostudies-literatureUnknown14(1)<h4>Background</h4>Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4⁺ tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA desaturase (SCD) increased by treatment with cancer-associated fibroblast (CAF) supernatant in CD4⁺ T cells on their subset differentiation and activity of CD8⁺ T cells.<h4>Results</h4>In our study, we observed that CD4⁺ TILs had higher lipid droplet content than CD4⁺ splenic T cells. In tumor tissue, CAF-derived supernatant provided fatty acids to CD4⁺ TILs, which increased the expression of SCD and oleic acid (OA) content. IncreCell & bioscienceStearoyl-CoA desaturase in CD4⁺ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8⁺ T cells.PMC11566202RS-2023-002496672020R1A2C1010215RS-2024-00351740Yang YHwang SHKim YJung JHKim JWfalseStearoyl-CoA desaturase in CD4⁺ T cells suppresses tumor growth through activation of the CXCR3/CXCL11 axis in CD8⁺ T cells.<h4>Background</h4>Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of lipid metabolism in CD4⁺ tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role of stearoyl-CoA desaturase (SCD) increased by treatment with cancer-associated fibroblast (CAF) supernatant in CD4⁺ T cells on their subset differentiation and activity of CD8⁺ T cells.<h4>Results</h4>In our study, we observed that CD4⁺ TILs had higher lipid droplet content than CD4⁺ splenic T cells. In tumor tissue, CAF-derived supernatant provided fatty acids to CD4⁺ TILs, which increased the expression of SCD and oleic acid (OA) content. Incre2024-01-01T00:00:00Z2024 Nov2026-07-16T22:37:25.546Z2025-04-06T01:39:47.349ZS-EPMC115662023954365010.1186/s13578-024-01308-3