biostudies-literatureLi WFundamental Research Funds for the Central UniversitiesNational Natural Science Foundation of ChinaStanley Foundation from the Stanley Medical Research Institute (SMRI), United States138https://www.ebi.ac.uk/biostudies/studies/S-EPMC11566632biostudies-literatureUnknown14(1)<h4>Background</h4>Increasingly studies highlight the crucial role of the ancestral retrovirus envelope protein ERVWE1 in the pathogenic mechanisms of schizophrenia, a severe psychiatric disorder affecting approximately 1% of the global population. Recent studies also underscore the significance of circular RNAs (circRNAs), crucial for neurogenesis and synaptogenesis, in maintaining neuronal functions. However, the precise relationship between ERVWE1 and circRNAs in the etiology of schizophrenia remains elusive.<h4>Results</h4>This study observed elevated levels of hsa_circ_0001810 (circ_0001810) in the blood samples of schizophrenia patients, displaying a significant positive correlation with ERVWE1 expression. Interestingly, in vivo studies demonstrated that ERVWE1 upregulated circ_00018Cell & bioscienceAncestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2.PMC11566632822723212042023kf0230No.06R-136681971943Li WXia YLi XZhou PZhang JZhu FZhang MXue XWu XfalseAncestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2.<h4>Background</h4>Increasingly studies highlight the crucial role of the ancestral retrovirus envelope protein ERVWE1 in the pathogenic mechanisms of schizophrenia, a severe psychiatric disorder affecting approximately 1% of the global population. Recent studies also underscore the significance of circular RNAs (circRNAs), crucial for neurogenesis and synaptogenesis, in maintaining neuronal functions. However, the precise relationship between ERVWE1 and circRNAs in the etiology of schizophrenia remains elusive.<h4>Results</h4>This study observed elevated levels of hsa_circ_0001810 (circ_0001810) in the blood samples of schizophrenia patients, displaying a significant positive correlation with ERVWE1 expression. Interestingly, in vivo studies demonstrated that ERVWE1 upregulated circ_000182024-01-01T00:00:00Z2024 Nov2026-06-02T03:36:40.112Z2025-04-19T16:11:02.704ZS-EPMC115666323954376710.1186/s13578-024-01318-1