biostudies-literatureUnknown10(21)Masooma<h4>Background</h4>Viruses cause various human diseases, some of which become pandemic outbreaks lack effective treatments and vaccines. This study gathered data on Carica papaya's antiviral effects against various human viruses, highlighting its potential as a natural treatment. Through <i>in-vitro</i>, <i>in-vivo</i>, and clinical study analysis, we illustrated the potential of Carica papaya in combating viral infections and its potential role in cure of common viral diseases.<h4>Method</h4>ology: Research papers on antiviral activity of Carica papaya were identified by using specific keywords in PUBMED, Google Scholar, and ScienceDirect databases. Articles published between January 2015 and March 2024 were screened for inclusion. Eligible studies utilized Carica papaya leaves (powder orHeliyone39635https://www.ebi.ac.uk/biostudies/studies/S-EPMC11566848biostudies-literatureProspects of <i>Carica papaya</i> in the treatment of human viral infections: A comprehensive and a systematic review.PMC11566848Qaiser AManzoor DSAli DSMasoomafalseProspects of <i>Carica papaya</i> in the treatment of human viral infections: A comprehensive and a systematic review.<h4>Background</h4>Viruses cause various human diseases, some of which become pandemic outbreaks lack effective treatments and vaccines. This study gathered data on Carica papaya's antiviral effects against various human viruses, highlighting its potential as a natural treatment. Through <i>in-vitro</i>, <i>in-vivo</i>, and clinical study analysis, we illustrated the potential of Carica papaya in combating viral infections and its potential role in cure of common viral diseases.<h4>Method</h4>ology: Research papers on antiviral activity of Carica papaya were identified by using specific keywords in PUBMED, Google Scholar, and ScienceDirect databases. Articles published between January 2015 and March 2024 were screened for inclusion. Eligible studies utilized Carica papaya leaves (powder or2024-01-01T00:00:00Z2024 Nov2025-04-18T12:47:12.579Z2025-04-06T22:10:01.108ZS-EPMC115668483955363510.1016/j.heliyon.2024.e39635