biostudies-literatureYe JRKyung Hee University1382https://www.ebi.ac.uk/biostudies/studies/S-EPMC11566898biostudies-literatureUnknown24(1)<h4>Background</h4>Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model.<h4>Methods</h4>Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20 µg/mL) for 72 h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration/proliferation potential of oxyresveratrol under lipopolysaccharide stiBMC oral healthEffect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment.PMC1156689820230360Lee HSKang SWChoi SCChae YKYe JRKwack KHPark SHNam OHfalseEffect of oxyresveratrol under in vitro lipopolysaccharide-induced periodontitis environment.<h4>Background</h4>Oxyresveratrol is the main constituent of mulberries and has many bioactive properties beneficial to human health. The purpose of this study was to assess the anti-inflammatory effects of oxyresveratrol on in vitro periodontitis model.<h4>Methods</h4>Human periodontal ligament cells were treated with oxyresveratrol (0, 10, and 20 µg/mL) for 72 h. Cell viability and flow cytometry assays were performed. To investigate anti-inflammatory effect of oxyresveratrol on periodontal inflammation, nitric oxide production under lipopolysaccharide stimulation was assessed. Next, expression of biomarkers associated periodontal inflammation was evaluated. Scratch wound assay was performed to evaluate cell migration/proliferation potential of oxyresveratrol under lipopolysaccharide sti2024-01-01T00:00:00Z2024 Nov2026-06-02T10:47:36.575Z2025-04-04T00:22:00.252ZS-EPMC115668983954843410.1186/s12903-024-05128-2