{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Panpetch W"],"funding":["Program Management Unit for Human Resources & Institutional Development, Research and Innovation","Rachadapisek Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University","National Research Council of Thailand","Thailand Science Research and Innovation Fund Chulalongkorn University","Rachadapisek Sompote Matching Fund"],"pagination":["e0309106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11567622"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(11)"],"pubmed_abstract":["The impact of Pseudomonas aeruginosa (PA) was explored in a mouse model with non-diarrheal gut permeability defect using 1.5% dextran sulfate solution (DSS) plus antibiotics (ATB) with or without orally administered PA. As such, ATB+DSS+PA mice induced more severe intestinal injury as indicated by stool consistency and leaky gut (FITC-dextran assay, bacteremia, and endotoxemia) with an increase in serum cytokines, liver enzyme, and hepatocyte apoptosis when compared with ATB+DSS mice. There was no abnormality by these parameters in the non-DSS group, including water alone (control), antibiotics alone (ATB+water), and antibiotics with PA (ATB+water+PA). Despite a similarly fecal microbiome patterns between ATB+DSS and ATB+DSS+PA groups, a higher abundance of Pseudomonas, Enterococci, and Es"],"journal":["PloS one"],"pubmed_title":["Presence of Pseudomonas aeruginosa in feces exacerbate leaky gut in mice with low dose dextran sulfate solution, impacts of specific bacteria."],"pmcid":["PMC11567622"],"funding_grant_id":["B16F640175 and B48G660112","HEAF67300087","RA-MF-22/65, RA-MF-13/66, and RA-MF-eAsia","NRCT-N41A640076 and NRCT-N34A660583"],"pubmed_authors":["Tumwasorn S","Panpetch W","Leelahavanichkul A"],"additional_accession":[]},"is_claimable":false,"name":"Presence of Pseudomonas aeruginosa in feces exacerbate leaky gut in mice with low dose dextran sulfate solution, impacts of specific bacteria.","description":"The impact of Pseudomonas aeruginosa (PA) was explored in a mouse model with non-diarrheal gut permeability defect using 1.5% dextran sulfate solution (DSS) plus antibiotics (ATB) with or without orally administered PA. As such, ATB+DSS+PA mice induced more severe intestinal injury as indicated by stool consistency and leaky gut (FITC-dextran assay, bacteremia, and endotoxemia) with an increase in serum cytokines, liver enzyme, and hepatocyte apoptosis when compared with ATB+DSS mice. There was no abnormality by these parameters in the non-DSS group, including water alone (control), antibiotics alone (ATB+water), and antibiotics with PA (ATB+water+PA). Despite a similarly fecal microbiome patterns between ATB+DSS and ATB+DSS+PA groups, a higher abundance of Pseudomonas, Enterococci, and Es","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T07:18:27.784Z","creation":"2025-04-06T22:46:23.056Z"},"accession":"S-EPMC11567622","cross_references":{"pubmed":["39546435"],"doi":["10.1371/journal.pone.0309106"]}}