biostudies-literatureYang DMedical Research Councile334https://www.ebi.ac.uk/biostudies/studies/S-EPMC11567688biostudies-literatureUnknown8(5)<h4>Background</h4>The minimum mortality temperature (MMT) or MMT percentile (MMTP) is an indicator of population susceptibility to nonoptimum temperatures. MMT and MMTP change over time; however, the changing directions show region-wide heterogeneity. We examined the heterogeneity of temporal changes in MMT and MMTP across multiple communities and in multiple countries.<h4>Methods</h4>Daily time-series data for mortality and ambient mean temperature for 699 communities in 34 countries spanning 1986-2015 were analyzed using a two-stage meta-analysis. First, a quasi-Poisson regression was employed to estimate MMT and MMTP for each community during the designated subperiods. Second, we pooled the community-specific temporally varying estimates using mixed-effects meta-regressions to examine Environmental epidemiology (Philadelphia, Pa.)Temporal change in minimum mortality temperature under changing climate: A multicountry multicommunity observational study spanning 1986-2015.PMC11567688MR/V034162/1MR/R013349/1Rao SHuber VGuo YRyti NOsorio SGoodman PArmstrong BKatsouyanni KMayvaneh FTobias AScovronick NZeka ASaldiva PHNKysely JChung YHashizume MVicedo-Cabrera AMYang DGasparrini AIndermitte EAmeling CDang TNLi SLavigne EOvercenco AForsberg BGuo YLNunes BDiaz MHPascal MAlahmad BHouthuijs DKim HOh JZanobetti ARagettli MSla Cruz Valencia CRoye DCoelho MSZSMichelozzi PMadureira JSchneider AHolo-Bac IHAbrutzky RIniguez CJaakkola JPan SCUrban ATong SSera FCorrea PMOrru HAcquaotta Fde'Donato FSchwartz JAnalitis AOrtega NVEntezari AHonda YKim YLee WfalseTemporal change in minimum mortality temperature under changing climate: A multicountry multicommunity observational study spanning 1986-2015.<h4>Background</h4>The minimum mortality temperature (MMT) or MMT percentile (MMTP) is an indicator of population susceptibility to nonoptimum temperatures. MMT and MMTP change over time; however, the changing directions show region-wide heterogeneity. We examined the heterogeneity of temporal changes in MMT and MMTP across multiple communities and in multiple countries.<h4>Methods</h4>Daily time-series data for mortality and ambient mean temperature for 699 communities in 34 countries spanning 1986-2015 were analyzed using a two-stage meta-analysis. First, a quasi-Poisson regression was employed to estimate MMT and MMTP for each community during the designated subperiods. Second, we pooled the community-specific temporally varying estimates using mixed-effects meta-regressions to examine 2024-01-01T00:00:00Z2024 Oct2026-07-17T00:03:19.97Z2025-04-03T23:23:48.1ZS-EPMC115676883955518510.1097/EE9.0000000000000334