{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dardano M"],"funding":["Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research)","Deutsche Forschungsgemeinschaft (German Research Foundation)"],"pagination":["1984-1996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11567889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(11)"],"pubmed_abstract":["Despite the biomedical importance of haematopoietic stem cells and haematopoietic progenitor cells, their in vitro stabilization in a developmental context has not been achieved due to limited knowledge of signals and markers specifying the multiple haematopoietic waves as well as ethically restricted access to the human embryo. Thus, an in vitro approach resembling aspects of haematopoietic development in the context of neighbouring tissues is of interest. Our established human pluripotent stem cell-derived heart-forming organoids (HFOs) recapitulate aspects of heart, vasculature and foregut co-development. Modulating HFO differentiation, we here report the generation of blood-generating HFOs. While maintaining a functional ventricular-like heart anlagen, blood-generating HFOs comprise a "],"journal":["Nature cell biology"],"pubmed_title":["Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart."],"pmcid":["PMC11567889"],"funding_grant_id":["EXC 62/2","01EK2108A","031L0249"],"pubmed_authors":["Kosanke M","Zweigerdt R","Kleemiß F","Lang D","Franke A","Wilson L","Shivaraj A","Teske J","Drakhlis L","Dardano M","de la Roche J","Fischer M","Schambach A","Lange L"],"additional_accession":[]},"is_claimable":false,"name":"Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart.","description":"Despite the biomedical importance of haematopoietic stem cells and haematopoietic progenitor cells, their in vitro stabilization in a developmental context has not been achieved due to limited knowledge of signals and markers specifying the multiple haematopoietic waves as well as ethically restricted access to the human embryo. Thus, an in vitro approach resembling aspects of haematopoietic development in the context of neighbouring tissues is of interest. Our established human pluripotent stem cell-derived heart-forming organoids (HFOs) recapitulate aspects of heart, vasculature and foregut co-development. Modulating HFO differentiation, we here report the generation of blood-generating HFOs. While maintaining a functional ventricular-like heart anlagen, blood-generating HFOs comprise a ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-05T08:42:12.027Z","creation":"2025-04-07T04:32:12.273Z"},"accession":"S-EPMC11567889","cross_references":{"pubmed":["39379702"],"doi":["10.1038/s41556-024-01526-4"]}}