biostudies-literatureYan QResearch Project of Chengdu Health CommissionSichuan Medical Research Youth Innovation Project of Sichuan Medical AssociationTechnological Innovation Research and Development Projects of Chengdu Science and Technology Bureau956https://www.ebi.ac.uk/biostudies/studies/S-EPMC11568672biostudies-literatureUnknown24(1)<h4>Background</h4>Epithelioid Hemangioendothelioma (EHE) is an extremely rare malignancy originating from endothelial cells, with an incidence rate of less than 1/100,000. To date, there have been no documented cases of Diaphragm EHE in the English or Chinese literature. EHE can manifest in various organs throughout the body and lacks distinctive clinical features, often leading to misdiagnosis. Given its rarity, there is currently no standardized treatment protocol, management options include radiotherapy, chemotherapy, and targeted therapy. In this report, we present a case study of a 75-year-old male patient who presented with a 6-month history of cough, sputum production, chest tightness, and pleural effusion. A biopsy of the diaphragm mass and immunohistochemical analysis of the pleuBMC geriatricsDiaphragm epithelioid hemangioendothelioma: a rare case report.PMC115686722023108Q211022022-YF05-01677-SNChen NYan QLi STang SZhang LHe LfalseDiaphragm epithelioid hemangioendothelioma: a rare case report.<h4>Background</h4>Epithelioid Hemangioendothelioma (EHE) is an extremely rare malignancy originating from endothelial cells, with an incidence rate of less than 1/100,000. To date, there have been no documented cases of Diaphragm EHE in the English or Chinese literature. EHE can manifest in various organs throughout the body and lacks distinctive clinical features, often leading to misdiagnosis. Given its rarity, there is currently no standardized treatment protocol, management options include radiotherapy, chemotherapy, and targeted therapy. In this report, we present a case study of a 75-year-old male patient who presented with a 6-month history of cough, sputum production, chest tightness, and pleural effusion. A biopsy of the diaphragm mass and immunohistochemical analysis of the pleu2024-01-01T00:00:00Z2024 Nov2025-04-03T23:23:50.903Z2025-04-03T23:23:50.903ZS-EPMC115686723955057010.1186/s12877-024-05536-7