biostudies-literatureBandres-Ciga SNational Institute of Neurological Disorders and StrokeIntramural NIH HHSNIA NIH HHSMichael J. Fox Foundation for Parkinson's ResearchNINDS NIH HHSNational Institute on AgingMichael J. Fox Foundation for Parkinson&apos;s Research2039-2048https://www.ebi.ac.uk/biostudies/studies/S-EPMC11568947biostudies-literatureUnknown39(11)<h4>Background</h4>Commercial genome-wide genotyping arrays have historically neglected coverage of genetic variation across populations.<h4>Objective</h4>We aimed to create a multi-ancestry genome-wide array that would include a wide range of neuro-specific genetic content to facilitate genetic research in neurological disorders across multiple ancestral groups, fostering diversity and inclusivity in research studies.<h4>Methods</h4>We developed the Illumina NeuroBooster Array (NBA), a custom high-throughput and cost-effective platform on a backbone of 1,914,934 variants from the Infinium Global Diversity Array and added custom content comprising 95,273 variants associated with more than 70 neurological conditions or traits, and we further tested its performance on more than 2000 patient Movement disorders : official journal of the Movement Disorder SocietyNeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.PMC11568947MJFF‐009421/17483ZIA NS003154AG000535ZIA AG000949Z99 AG999999MJFF-009421/17483Jeff JRiley EQuinn JPHardy JJabbari EDumanis SHernandez DGKim JBlauwendraat CKoretsky MJArepalli SReyes-Palomares AVitale DLevine KSFaghri FIwaki HCrea PWNarendra DSingleton AHoulden HLohmann KMajounie EBandres-Ciga STraynor BJMakarious MBKlein CGlobal Parkinson's Genetics Program (GP2) and the Center for Alzheimer's and Related Dementias (CARD)Schulte CLubbe SJBillingsley KMorris HRNalls MLeonard HSaffie-Awad PScholz SWfalseNeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.<h4>Background</h4>Commercial genome-wide genotyping arrays have historically neglected coverage of genetic variation across populations.<h4>Objective</h4>We aimed to create a multi-ancestry genome-wide array that would include a wide range of neuro-specific genetic content to facilitate genetic research in neurological disorders across multiple ancestral groups, fostering diversity and inclusivity in research studies.<h4>Methods</h4>We developed the Illumina NeuroBooster Array (NBA), a custom high-throughput and cost-effective platform on a backbone of 1,914,934 variants from the Infinium Global Diversity Array and added custom content comprising 95,273 variants associated with more than 70 neurological conditions or traits, and we further tested its performance on more than 2000 patient 2024-01-01T00:00:00Z2024 Nov2026-05-15T03:20:35.444Z2026-05-15T03:12:48.55ZS-EPMC115689473928329410.1002/mds.29902