{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ripmeester EGJ"],"funding":["Stichting De Weijerhorst","Dutch Arthritis Association"],"pagination":["495-506"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11569685"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(4)"],"pubmed_abstract":["ObjectiveOsteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]). The disease-modifying action of the p[63-82] was followed-up in this model for 5 and 10 weeks.DesignSkeletally mature male Lewis rats underwent ACLT-pMMx surgery. Rats received weekl"],"journal":["Cartilage"],"pubmed_title":["The BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis."],"pmcid":["PMC11569685"],"funding_grant_id":["Grants: LLP14, 13-02-201, 15-03-403"],"pubmed_authors":["Pitelka V","Ripmeester EGJ","Wijnands KAP","Stassen RHMJ","Steijns JSJJ","van Rietbergen B","Surtel DAM","van Rhijn LW","van den Akker GGH","Caron MMJ","Astryde NMSA","Peeters LCW","Cremers A","Welting TJM","Emans PJ","Chabronova A"],"additional_accession":[]},"is_claimable":false,"name":"The BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis.","description":"ObjectiveOsteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]). The disease-modifying action of the p[63-82] was followed-up in this model for 5 and 10 weeks.DesignSkeletally mature male Lewis rats underwent ACLT-pMMx surgery. Rats received weekl","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-02T03:18:56.955Z","creation":"2025-04-03T23:23:54.632Z"},"accession":"S-EPMC11569685","cross_references":{"pubmed":["38501739"],"doi":["10.1177/19476035241233659"]}}