biostudies-literatureRipmeester EGJStichting De WeijerhorstDutch Arthritis Association495-506https://www.ebi.ac.uk/biostudies/studies/S-EPMC11569685biostudies-literatureUnknown16(4)ObjectiveOsteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]). The disease-modifying action of the p[63-82] was followed-up in this model for 5 and 10 weeks.DesignSkeletally mature male Lewis rats underwent ACLT-pMMx surgery. Rats received weeklCartilageThe BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis.PMC11569685Grants: LLP14, 13-02-201, 15-03-403Pitelka VRipmeester EGJWijnands KAPStassen RHMJSteijns JSJJvan Rietbergen BSurtel DAMvan Rhijn LWvan den Akker GGHCaron MMJAstryde NMSAPeeters LCWCremers AWelting TJMEmans PJChabronova AfalseThe BMP7-Derived Peptide p[63-82] Reduces Cartilage Degeneration in the Rat ACLT-pMMx Model for Posttraumatic Osteoarthritis.ObjectiveOsteoarthritis (OA) is characterized by articular cartilage erosion, pathological subchondral bone changes, and signs of synovial inflammation and pain. We previously identified p[63-82], a bone morphogenetic protein 7 (BMP7)-derived bioactive peptide that attenuates structural cartilage degeneration in the rat medial meniscal tear-model for posttraumatic OA. This study aimed to evaluate the cartilage erosion-attenuating activity of p[63-82] in a different preclinical model for OA (anterior cruciate ligament transection-partial medial meniscectomy [anterior cruciate ligament transection (ACLT)-pMMx]). The disease-modifying action of the p[63-82] was followed-up in this model for 5 and 10 weeks.DesignSkeletally mature male Lewis rats underwent ACLT-pMMx surgery. Rats received weekl2025-01-01T00:00:00Z2025 Dec2026-06-02T03:18:56.955Z2025-04-03T23:23:54.632ZS-EPMC115696853850173910.1177/19476035241233659