{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Berek K"],"funding":["Tiroler Wissenschaftsförderung"],"pagination":["e70165"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11570677"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(11)"],"pubmed_abstract":["<h4>Background</h4>Neurological symptoms are common in acute mountain sickness (AMS); however, the extent of neuroaxonal damage remains unclear. Neurofilament light chain (NfL) is an established blood biomarker for neuroaxonal damage.<h4>Objective</h4>To investigate whether plasma (p) NfL levels increase after simulated altitude exposure, correlate with the occurrence of AMS, and might be mitigated by preacclimatization.<h4>Methods</h4>Healthy subjects were exposed to simulated high altitude (4500 m) by the use of a normobaric hypoxic chamber at the University of Innsbruck two times, that is, within Cycle 1 (C1) over 12 h, and within Cycle 2 (C2) for another 12 h but with a random assignment to prior acclimatization or sham acclimatization. Before each cycle (measurement [M] 1 and 3) and a"],"journal":["Brain and behavior"],"pubmed_title":["Neurofilament Light Chain Is Associated With Acute Mountain Sickness."],"pmcid":["PMC11570677"],"funding_grant_id":["F430.68"],"pubmed_authors":["Bsteh G","Berek K","Hegen H","Wille M","Burtscher M","Lindner A","Ponleitner M","Deisenhammer F","Engler C","Pauli FD","Treml B","Kleinsasser A","Berger T"],"additional_accession":[]},"is_claimable":false,"name":"Neurofilament Light Chain Is Associated With Acute Mountain Sickness.","description":"<h4>Background</h4>Neurological symptoms are common in acute mountain sickness (AMS); however, the extent of neuroaxonal damage remains unclear. Neurofilament light chain (NfL) is an established blood biomarker for neuroaxonal damage.<h4>Objective</h4>To investigate whether plasma (p) NfL levels increase after simulated altitude exposure, correlate with the occurrence of AMS, and might be mitigated by preacclimatization.<h4>Methods</h4>Healthy subjects were exposed to simulated high altitude (4500 m) by the use of a normobaric hypoxic chamber at the University of Innsbruck two times, that is, within Cycle 1 (C1) over 12 h, and within Cycle 2 (C2) for another 12 h but with a random assignment to prior acclimatization or sham acclimatization. Before each cycle (measurement [M] 1 and 3) and a","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-16T23:54:25.078Z","creation":"2025-04-04T02:51:14.249Z"},"accession":"S-EPMC11570677","cross_references":{"pubmed":["39552103"],"doi":["10.1002/brb3.70165"]}}