biostudies-literatureLiu ZNational Major Science and Technology Projects of ChinaBasic and Applied Basic Research Foundation of Guangdong ProvinceGuangdong Provincial Natural Science FoundationNational Natural Science Foundation of China104463https://www.ebi.ac.uk/biostudies/studies/S-EPMC11570720biostudies-literatureUnknown103(12)The excessive accumulation of abdominal fat in chickens has resulted in a reduction in both the feed conversion efficiency and the slaughter yield. To elucidate the regulatory mechanisms and metabolic pathways affecting abdominal fat deposition in the context of broiler breeding, a cohort of 400 Qingyuan partridge chickens with varying abdominal fat deposition was established. Whole transcriptome sequencing analyses were conducted on the duodenum of 20 representative chickens to ascertain the regulatory networks at this vital digestive and absorptive organ. Consequently, 116 differentially expressed genes were identified, exhibiting a trend of increasing or decreasing expression in correlation with the accumulation of abdominal fat. A total of 36 DEmRNAs, 170 DElncRNAs, 92 DEcircRNAs and 8Poultry scienceCharacterization of the regulatory network and pathways in duodenum affecting chicken abdominal fat deposition.PMC115707202023ZD040642022A151501201432102538Cheng SLi HLiu ZKang HZhang ZZhang XYang MMa ZXiang HYe FWei JfalseCharacterization of the regulatory network and pathways in duodenum affecting chicken abdominal fat deposition.The excessive accumulation of abdominal fat in chickens has resulted in a reduction in both the feed conversion efficiency and the slaughter yield. To elucidate the regulatory mechanisms and metabolic pathways affecting abdominal fat deposition in the context of broiler breeding, a cohort of 400 Qingyuan partridge chickens with varying abdominal fat deposition was established. Whole transcriptome sequencing analyses were conducted on the duodenum of 20 representative chickens to ascertain the regulatory networks at this vital digestive and absorptive organ. Consequently, 116 differentially expressed genes were identified, exhibiting a trend of increasing or decreasing expression in correlation with the accumulation of abdominal fat. A total of 36 DEmRNAs, 170 DElncRNAs, 92 DEcircRNAs and 82024-01-01T00:00:00Z2024 Dec2026-07-16T23:50:08.812Z2025-04-07T10:10:10.956ZS-EPMC115707203950482110.1016/j.psj.2024.104463