biostudies-literatureYuan YSun Yat-Sen University Clinical Research 5010 ProgrammeNational Natural Science Foundation of China1337-1349https://www.ebi.ac.uk/biostudies/studies/S-EPMC11570767biostudies-literatureUnknown44(11)<h4>Background</h4>The widely accepted view that portal hypertension (PHT) is a contraindication to hepatectomy for patients with hepatocellular carcinoma (HCC) is being increasingly challenged. The long-term survival outcomes and safety of partial hepatectomy versus interventional treatment using ablation with or without pre-ablation transarterial chemoembolization (TACE) in patients with HBV-related HCC within the Milan criteria and with clinically significant PHT were compared in this study.<h4>Methods</h4>This open-label randomized clinical trial was conducted on consecutive patients with clinically PHT and hepatitis B virus (HBV)-related HCC with tumors which were within the Milan criteria. These patients were randomized 1:1 to receive either partial hepatectomy or interventional treaCancer communications (London, England)Partial hepatectomy versus interventional treatment in patients with hepatitis B virus-related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinical trial.PMC11570767No. 822728872012010Peng HQiu JZheng YHe WWang CZou RLi BChen BLau WYYuan YfalsePartial hepatectomy versus interventional treatment in patients with hepatitis B virus-related hepatocellular carcinoma and clinically significant portal hypertension: a randomized comparative clinical trial.<h4>Background</h4>The widely accepted view that portal hypertension (PHT) is a contraindication to hepatectomy for patients with hepatocellular carcinoma (HCC) is being increasingly challenged. The long-term survival outcomes and safety of partial hepatectomy versus interventional treatment using ablation with or without pre-ablation transarterial chemoembolization (TACE) in patients with HBV-related HCC within the Milan criteria and with clinically significant PHT were compared in this study.<h4>Methods</h4>This open-label randomized clinical trial was conducted on consecutive patients with clinically PHT and hepatitis B virus (HBV)-related HCC with tumors which were within the Milan criteria. These patients were randomized 1:1 to receive either partial hepatectomy or interventional trea2024-01-01T00:00:00Z2024 Nov2026-07-15T04:58:55.256Z2025-04-21T21:45:48.286ZS-EPMC115707673932295110.1002/cac2.12614