biostudies-literatureUnknown20Tsuruta K<h4>Aim</h4>To investigate the effects of hemoglobin vesicles (HbVs) in preventing hypoxic brain injury after cardiac arrest in a rat model of asphyxia-related cardiac arrest.<h4>Methods</h4>Male Wistar rats were divided into three groups: HbVs (n = 18), control (n = 29), and sham (n = 7). Respiratory arrest was induced using muscle relaxants under ventilation. Cardiac arrest occurred 3-4 min later. After 8 min, HbVs or saline (5 ml/kg), adrenaline, and sodium bicarbonate were administered, followed by chest compressions and ventilation. Resuscitation was deemed successful with a mean arterial pressure > 60 mmHg sustained for at least 5 min. Behavioral and histopathological evaluations were performed 7 days later.<h4>Results</h4>Survival rates were 39 % and 24 % in the HbVs and control groResuscitation plus100819https://www.ebi.ac.uk/biostudies/studies/S-EPMC11570973biostudies-literatureHemoglobin vesicles improve neurological outcomes after cardiac arrest in rats.PMC11570973Sakai HTsuruta KFukushima HfalseHemoglobin vesicles improve neurological outcomes after cardiac arrest in rats.<h4>Aim</h4>To investigate the effects of hemoglobin vesicles (HbVs) in preventing hypoxic brain injury after cardiac arrest in a rat model of asphyxia-related cardiac arrest.<h4>Methods</h4>Male Wistar rats were divided into three groups: HbVs (n = 18), control (n = 29), and sham (n = 7). Respiratory arrest was induced using muscle relaxants under ventilation. Cardiac arrest occurred 3-4 min later. After 8 min, HbVs or saline (5 ml/kg), adrenaline, and sodium bicarbonate were administered, followed by chest compressions and ventilation. Resuscitation was deemed successful with a mean arterial pressure > 60 mmHg sustained for at least 5 min. Behavioral and histopathological evaluations were performed 7 days later.<h4>Results</h4>Survival rates were 39 % and 24 % in the HbVs and control gro2024-01-01T00:00:00Z2024 Dec2025-04-04T02:50:59.28Z2025-04-04T02:50:59.28ZS-EPMC115709733955973010.1016/j.resplu.2024.100819