{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(49)"],"submitter":["Sethi A"],"pubmed_abstract":["Sugar mimics are valuable tools in medicinal chemistry, offering the potential to overcome the limitations of carbohydrate inhibitors, such as poor pharmacokinetics and non-selectivity. In our continued efforts to develop heterocyclic galectin-1 inhibitors, we report the synthesis and characterization of thiazole-linked coumarin piperazine hybrids (10a-10i) as Gal-1 inhibitors. The compounds were characterized using <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. Among the synthesized molecules, four compounds demonstrated significant inhibitory activity, with more than 50% inhibition observed at a concentration of 20 μM in a Gal-1 enzyme assay. Fluorescence spectroscopy was further utilized to elucidate the binding constant for the synthesized compounds. 10g exhibited the highest affinity"],"journal":["RSC advances"],"pagination":["36794-36803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11571122"],"repository":["biostudies-literature"],"pubmed_title":["Sugar mimics and their probable binding sites: design and synthesis of thiazole linked coumarin-piperazine hybrids as galectin-1 inhibitors."],"pmcid":["PMC11571122"],"pubmed_authors":["Sethi A","Kumar J","Alvala M","Vemula D","Qureshi IA","Gadde D","Talla V"],"additional_accession":[]},"is_claimable":false,"name":"Sugar mimics and their probable binding sites: design and synthesis of thiazole linked coumarin-piperazine hybrids as galectin-1 inhibitors.","description":"Sugar mimics are valuable tools in medicinal chemistry, offering the potential to overcome the limitations of carbohydrate inhibitors, such as poor pharmacokinetics and non-selectivity. In our continued efforts to develop heterocyclic galectin-1 inhibitors, we report the synthesis and characterization of thiazole-linked coumarin piperazine hybrids (10a-10i) as Gal-1 inhibitors. The compounds were characterized using <sup>1</sup>H NMR, <sup>13</sup>C NMR and HRMS. Among the synthesized molecules, four compounds demonstrated significant inhibitory activity, with more than 50% inhibition observed at a concentration of 20 μM in a Gal-1 enzyme assay. Fluorescence spectroscopy was further utilized to elucidate the binding constant for the synthesized compounds. 10g exhibited the highest affinity","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-06-02T04:02:38.487Z","creation":"2025-04-21T21:41:12.969Z"},"accession":"S-EPMC11571122","cross_references":{"pubmed":["39559576"],"doi":["10.1039/d4ra06715k"]}}