{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20"],"submitter":["Bilska-Markowska M"],"pubmed_abstract":["The incorporation of fluorine atoms within the structure of organic compounds is known to exert a significant impact on their electronic properties, thereby modulating their reactivity in diverse chemical transformations. In the context of our investigation, we observed a striking illustration of this phenomenon. A Michael addition involving <i>gem</i>-difluorovinyl and trifluorovinyl acceptors was successfully achieved, demonstrating high stereoselectivity. This selectivity was further elucidated through theoretical calculations. Using this methodology, a series of new α,β-unsaturated amides, both fluorinated and nonfluorinated, were synthesized."],"journal":["Beilstein journal of organic chemistry"],"pagination":["2946-2953"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11572014"],"repository":["biostudies-literature"],"pubmed_title":["&lt;i&gt;gem&lt;/i&gt;-Difluorovinyl and trifluorovinyl Michael acceptors in the synthesis of α,β-unsaturated fluorinated and nonfluorinated amides."],"pmcid":["PMC11572014"],"pubmed_authors":["Kazmierczak M","Hoffmann M","Jankowski W","Bilska-Markowska M"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;gem&lt;/i&gt;-Difluorovinyl and trifluorovinyl Michael acceptors in the synthesis of α,β-unsaturated fluorinated and nonfluorinated amides.","description":"The incorporation of fluorine atoms within the structure of organic compounds is known to exert a significant impact on their electronic properties, thereby modulating their reactivity in diverse chemical transformations. In the context of our investigation, we observed a striking illustration of this phenomenon. A Michael addition involving <i>gem</i>-difluorovinyl and trifluorovinyl acceptors was successfully achieved, demonstrating high stereoselectivity. This selectivity was further elucidated through theoretical calculations. Using this methodology, a series of new α,β-unsaturated amides, both fluorinated and nonfluorinated, were synthesized.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2025-04-04T02:51:06.444Z","creation":"2025-04-04T02:51:06.444Z"},"accession":"S-EPMC11572014","cross_references":{"pubmed":["39559442"],"doi":["10.3762/bjoc.20.247"]}}