biostudies-literatureMendonca MDMichael J. Fox Foundation for Parkinson's Research (Michael J. Fox Foundation)EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)209https://www.ebi.ac.uk/biostudies/studies/S-EPMC11574046biostudies-literatureUnknown10(1)Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson's Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients. Furthermore, higher baseline CBR was linked to RT development. In the smaller cohorts, a 4-6 Hz oscillation-based metric from inertial sensors correlated with RT amplitude, distinguished controls from patients with reduced DaT binding and correlated with CBR in the latter group. In silico modelling uncovered that higher CBR in RT patients explained correlations bNPJ Parkinson's diseaseRelative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.PMC11574046H2020-SC1-DTH-2019-875358MJFF-023180Meira BMendonca MDCosta DCFerreira PCda Silva JABarbosa ROliveira FOliveira-Maia AJfalseRelative sparing of dopaminergic terminals in the caudate nucleus is a feature of rest tremor in Parkinson's disease.Resting tremor (RT) is a Parkinson's disease (PD) symptom with an unclear relationship to the dopaminergic system. We analysed data from 432 subjects from the Parkinson's Progression Markers Initiative, 57 additional PD patients and controls and 86 subjects referred for dopamine transporter single-photon emission computed tomography (DaT-SPECT). Caudate binding ratio (CBR), but not putamen binding ratio, was higher in RT patients. Furthermore, higher baseline CBR was linked to RT development. In the smaller cohorts, a 4-6 Hz oscillation-based metric from inertial sensors correlated with RT amplitude, distinguished controls from patients with reduced DaT binding and correlated with CBR in the latter group. In silico modelling uncovered that higher CBR in RT patients explained correlations b2024-01-01T00:00:00Z2024 Nov2026-05-29T11:52:30.935Z2025-04-05T20:00:35.135ZS-EPMC115740463955787110.1038/s41531-024-00818-8