{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tsai HJ"],"funding":["National Taiwan University Hospital","National Science and Technology Council"],"pagination":["383"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575159"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE) responsiveness (complete remission [CR] after HPE) in gastric mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Materials and methods</h4>We co-cultured three B-lymphoma cell lines (MA-1, OCI-Ly3, and OCI-Ly7) with HP strains (derived from HPE-responsive gastric MALT lymphoma) and evaluated the expression patterns of CagA, phosphorylated (p)-CagA (CagA<sup>P-Tyr</sup>), and CagA-signaling molecules, cell-cycle inhibitors, p-NFATc1 (Ser<sup>172</sup>), and NFATc1 using western blotting. Furthermore, we evaluated the association betwe"],"journal":["Cancer cell international"],"pubmed_title":["Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma."],"pmcid":["PMC11575159"],"funding_grant_id":["No. 110-2314-B-002-219-MY3, No. 112-2314-B-002-097-MY3, No. 112-2811-B-002-092-, and No. 113-2811-B-002-142","No. NTUH 113-S0087"],"pubmed_authors":["Chen LT","Shun CT","Wang HP","Lin CW","Wei MF","Kuo SH","Zeng YS","Hsu PN","Tsai HJ","Wu MS","Liou JM","Yeh KH","Cheng AL"],"additional_accession":[]},"is_claimable":false,"name":"Cooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma.","description":"<h4>Background</h4>This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE) responsiveness (complete remission [CR] after HPE) in gastric mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Materials and methods</h4>We co-cultured three B-lymphoma cell lines (MA-1, OCI-Ly3, and OCI-Ly7) with HP strains (derived from HPE-responsive gastric MALT lymphoma) and evaluated the expression patterns of CagA, phosphorylated (p)-CagA (CagA<sup>P-Tyr</sup>), and CagA-signaling molecules, cell-cycle inhibitors, p-NFATc1 (Ser<sup>172</sup>), and NFATc1 using western blotting. Furthermore, we evaluated the association betwe","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Nov","modification":"2026-07-17T01:08:14.01Z","creation":"2025-04-04T20:38:48.117Z"},"accession":"S-EPMC11575159","cross_references":{"pubmed":["39558403"],"doi":["10.1186/s12935-024-03552-6"]}}