biostudies-literatureTsai HJNational Taiwan University HospitalNational Science and Technology Council383https://www.ebi.ac.uk/biostudies/studies/S-EPMC11575159biostudies-literatureUnknown24(1)<h4>Background</h4>This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE) responsiveness (complete remission [CR] after HPE) in gastric mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Materials and methods</h4>We co-cultured three B-lymphoma cell lines (MA-1, OCI-Ly3, and OCI-Ly7) with HP strains (derived from HPE-responsive gastric MALT lymphoma) and evaluated the expression patterns of CagA, phosphorylated (p)-CagA (CagA^P-Tyr), and CagA-signaling molecules, cell-cycle inhibitors, p-NFATc1 (Ser¹⁷²), and NFATc1 using western blotting. Furthermore, we evaluated the association betweCancer cell internationalCooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma.PMC11575159No. 110-2314-B-002-219-MY3, No. 112-2314-B-002-097-MY3, No. 112-2811-B-002-092-, and No. 113-2811-B-002-142No. NTUH 113-S0087Chen LTShun CTWang HPLin CWWei MFKuo SHZeng YSHsu PNTsai HJWu MSLiou JMYeh KHCheng ALfalseCooperative participation of CagA and NFATc1 in the pathogenesis of antibiotics-responsive gastric MALT lymphoma.<h4>Background</h4>This study aimed to explore whether cytotoxin-associated gene A (CagA) can inhibit cell cycle progression by activating nuclear factor of activated T cells (NFAT) in lymphoma B cells and contribute to Helicobacter pylori eradication (HPE) responsiveness (complete remission [CR] after HPE) in gastric mucosa-associated lymphoid tissue (MALT) lymphoma.<h4>Materials and methods</h4>We co-cultured three B-lymphoma cell lines (MA-1, OCI-Ly3, and OCI-Ly7) with HP strains (derived from HPE-responsive gastric MALT lymphoma) and evaluated the expression patterns of CagA, phosphorylated (p)-CagA (CagA^P-Tyr), and CagA-signaling molecules, cell-cycle inhibitors, p-NFATc1 (Ser¹⁷²), and NFATc1 using western blotting. Furthermore, we evaluated the association betwe2024-01-01T00:00:00Z2024 Nov2026-07-17T01:08:14.01Z2025-04-04T20:38:48.117ZS-EPMC115751593955840310.1186/s12935-024-03552-6